Literature DB >> 26596950

Evaluating 5-Nitrothiazoles as Trypanocidal Agents.

Ivan P O'Shea1, Mohammed Shahed1, Benjamín Aguilera-Venegas2, Shane R Wilkinson3.   

Abstract

The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26596950      PMCID： PMC4750693          DOI： 10.1128/AAC.02006-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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  5 in total

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