| Literature DB >> 26596552 |
Taotao Feng1, Xiaoyu Chen1, Xiuwen Qiao1, Zhao Sun1, Haining Wang1, Yu Qi2, Chenglin Hong3.
Abstract
In this work, a simple electrochemical immunosensor was developed for the detection of carcinoembryonic antigen (CEA) based on rhombic dodecahedral Cu2O nanocrystals-graphene oxide-gold nanoparticles (rCu2O-GO-AuNPs). GO as the template and surfactant resulting in rCu2O exhibit improved rhombic dodecahedral structure uniformity and excellent electrochemical performance. Moreover, GO was found to be able to effectively improve the long stability of rCu2O on the electrode response. Under optimal conditions, the immunosensor showed a low limit of detection (0.004 ng ml(-1)) and a large linear range (0.01-120 ng ml(-1)). This work presents a potential alternative for the diagnostic applications of GO-supported special morphology materials in biomedicine and biosensors.Entities:
Keywords: Carcinoembryonic antigen; Gold nanoparticles; Graphene oxide; Immunosensor; Rhombic dodecahedral Cu(2)O nanocrystals
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Year: 2015 PMID： 26596552 DOI： 10.1016/j.ab.2015.11.004
Source DB: PubMed Journal: Anal Biochem ISSN： 0003-2697 Impact factor: 3.365