| Literature DB >> 26595890 |
Marie B Iversen1,2, Line S Reinert1,2, Martin K Thomsen1,2, Ieva Bagdonaite3, Ramya Nandakumar1,2, Natalia Cheshenko4, Thaneas Prabakaran1,2, Sergey Y Vakhrushev3, Malgosha Krzyzowska5, Sine K Kratholm1,2, Fernando Ruiz-Perez6, Steen V Petersen1, Stanislas Goriely7, Bo Martin Bibby8, Kristina Eriksson9, Jürgen Ruland10, Allan R Thomsen11, Betsy C Herold4, Hans H Wandall3, Sebastian Frische1, Christian K Holm1,2, Søren R Paludan1,2.
Abstract
Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.Entities:
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Year: 2015 PMID： 26595890 DOI： 10.1038/ni.3319
Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606