Literature DB >> 2659569

Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.

G Franceschi1, E Perrone, M Alpegiani, A Bedeschi, C Battistini, F Zarini, C Della Bruna.   

Abstract

The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.

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Year:  1989        PMID： 2659569     DOI： 10.1093/jac/23.suppl_c.1

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  3 in total

1.  Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers.

Authors:  C Efthymiopoulos; M Strolin Benedetti; D Sassella; A Boobis; D Davies
Journal:  Antimicrob Agents Chemother       Date:  1992-09       Impact factor: 5.191

2.  Survey of in vitro susceptibilities of Vibrio cholerae O1 and O139 to antimicrobial agents.

Authors:  T Yamamoto; G B Nair; M J Albert; C C Parodi; Y Takeda
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

3.  Potent bacteriolytic activity of ritipenem associated with a characteristic profile of affinities for penicillin-binding proteins of Haemophilus influenzae.

Authors:  T Inui; T Oshida; T Endo; T Matsushita
Journal:  Antimicrob Agents Chemother       Date:  1999-10       Impact factor: 5.191
  3 in total

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