Literature DB >> 26592704

Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor.

Ryosuke Ueki1, Ayaka Ueki1, Naoto Kanda1, Shinsuke Sando2.   

Abstract

Oligonucleotide-based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss-0, which was composed solely of 100-mer single-stranded DNA, exhibited nanomolar potency. Aptamer ss-0 reproduced HGF-induced cellular behaviors, including migration and proliferation. The present work sheds light on oligonucleotides as a novel chemical entity for the design of growth factor mimetics.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA nanotechnology; aptamers; growth factors; receptors; signal transduction

Mesh：

Substances：

Year:  2015        PMID： 26592704     DOI： 10.1002/anie.201508572

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  17 in total

1.  MET-activating Residues in the B-repeat of the Listeria monocytogenes Invasion Protein InlB.

Authors:  Willem M Bleymüller; Nina Lämmermann; Maria Ebbes; Daniel Maynard; Christina Geerds; Hartmut H Niemann
Journal:  J Biol Chem       Date:  2016-10-27       Impact factor: 5.157

2.  Altered stoichiometry of an evolved RNA aptamer.

Authors:  Shoji Ohuchi; Beatrix Suess
Journal:  RNA       Date:  2017-12-28       Impact factor: 4.942

3.  MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.

Authors:  Wenyu Miao; Katsuya Sakai; Ryu Imamura; Kenichiro Ito; Hiroaki Suga; Tetsushi Sakuma; Takashi Yamamoto; Kunio Matsumoto
Journal:  Int J Mol Sci       Date:  2018-10-12       Impact factor: 5.923

4.  Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist.

Authors:  Wenyu Miao; Katsuya Sakai; Naoya Ozawa; Takumi Nishiuchi; Yoshinori Suzuki; Kenichiro Ito; Tomomi Morioka; Masataka Umitsu; Junichi Takagi; Hiroaki Suga; Kunio Matsumoto
Journal:  Sci Rep       Date:  2018-11-07       Impact factor: 4.379

5.  Binding and Structural Properties of DNA Aptamers with VEGF-A-Mimic Activity.

Authors:  Toru Yoshitomi; Misako Hayashi; Takumi Oguro; Keiko Kimura; Fumiya Wayama; Hitoshi Furusho; Keitaro Yoshimoto
Journal:  Mol Ther Nucleic Acids       Date:  2020-01-14       Impact factor: 8.886

Review 6.  Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application.

Authors:  Tatsuo Adachi; Yoshikazu Nakamura
Journal:  Molecules       Date:  2019-11-21       Impact factor: 4.411

7.  Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high-anticoagulant thrombin-binding bivalent DNA aptamer-linked M08 with HD22.

Authors:  Toru Yoshitomi; Koji Wakui; Masato Miyakawa; Keitaro Yoshimoto
Journal:  Res Pract Thromb Haemost       Date:  2021-06-05

Review 8.  HGF and MET: From Brain Development to Neurological Disorders.

Authors:  Claudia Desole; Simona Gallo; Annapia Vitacolonna; Francesca Montarolo; Antonio Bertolotto; Denis Vivien; Paolo Comoglio; Tiziana Crepaldi
Journal:  Front Cell Dev Biol       Date:  2021-06-09

9.  Simultaneous Monitoring of Cell-surface Receptor and Tumor-targeted Photodynamic Therapy via TdT-initiated Poly-G-Quadruplexes.

Authors:  Tianhui Shi; Menglin Wang; Hao Li; Miao Wang; Xingyu Luo; Yan Huang; Hong-Hui Wang; Zhou Nie; Shouzhuo Yao
Journal:  Sci Rep       Date:  2018-04-03       Impact factor: 4.379

10.  I-Motif/miniduplex hybrid structures bind benzothiazole dyes with unprecedented efficiencies: a generic light-up system for label-free DNA nanoassemblies and bioimaging.

Authors:  Lili Shi; Pai Peng; Jiao Zheng; Qiwei Wang; Zhijin Tian; Huihui Wang; Tao Li
Journal:  Nucleic Acids Res       Date:  2020-02-28       Impact factor: 16.971
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