| Literature DB >> 26590328 |
Longfei Shu1, Chunlin Wang1, Jinbiao Wang1, Yongming Zhang1, Xing Zhang1, Yanyan Yang1, Jianwei Zhuo1, Jiachuan Liu2.
Abstract
Hypoxic preconditioning (HPC) increases the inherent tolerance of brain tissue suffering from severe hypoxia or ischemia insult by stimulating the protective ability of the brain. However, little is known concerning the effect of HPC on traumatic brain injury (TBI). We designed this study to investigate the effect of HPC on TBI and explore its underlying mechanisms. We found that HPC significantly alleviates neurological dysfunction, lessens brain edema, reduces cell apoptosis, increases neuronal survival, up-regulates the expressions of Nrf2 and HO-1, and decreases the inducer of protein carbonyls, 4-hydroxy-2-nonenal, and 8-hydroxy-2-deoxyguanosine in the brain tissue of rats 24h after brain injury. However, no influence was observed in normal rats after only 3d of hypoxic training. Results further indicated that HPC protects the brain against traumatic damage. This protective effect may be achieved by up-regulating Nrf2 and HO-1 expression and alleviating oxidative stress damage.Entities:
Keywords: Heme oxygenase-1; Hypoxic preconditioning; Nuclear factor erythroid 2-related factor 2p; Traumatic brain injury
Mesh：
Substances：
Year: 2015 PMID： 26590328 DOI： 10.1016/j.neulet.2015.11.012
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046