Ultrastructural findings of Candida albicans blastoconidia submitted to the action of fenticonazole.

A study has been conducted about ultrastructural changes induced by an imidazole derivative, fenticonazole (Lomexin), on Candida albicans blastoconidia. The structural upset has been progressively exerted starting from coating membrane surfaces throughout cytosol components and nuclear compart, so that the existence can be assumed for a direct dependence of these changes upon activity failure by a few organules. Membrane permeability processes have resulted to be involved, which are the main metabolic paths in the defective ATP synthesis, and enzyme blockades responsible for peroxide accumulation.