Marissa G Baker1, Bert Stover2,3,4, Christopher D Simpson2, Lianne Sheppard2,5, Noah S Seixas2. 1. Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA, 98105, USA. bakermg@uw.edu. 2. Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Suite 100, Seattle, WA, 98105, USA. 3. Department of Health Services, University of Washington, Seattle, WA, USA. 4. Department of Family Medicine, University of Washington, Seattle, WA, USA. 5. Department of Biostatistics, University of Washington, Seattle, WA, USA.
Abstract
PURPOSE: We sought to understand the time course between exposure to manganese (Mn) and uptake into the blood, to allow a more meaningful interpretation of exposure biomarker data, and to determine the utility of blood as a biomarker of Mn exposure. METHODS: Welder trainees were monitored over the course of a five-quarter training program. Each quarter, trainees gave eight blood samples and had personal air monitoring four times. A mixed model was fit to obtain estimates of airborne exposure by welding type (fixed effect), adjusted for subject (random effect). Considering weekends and days absent as zero exposure, estimated exposures were summed over various exposure windows and related to measured blood manganese (MnB) using a mixed model. RESULTS: A relationship consistent with zero was found between MnB and modeled 1 or 7 days of exposure. After 30 days of preceding exposure, a 1 mg-days/m(3) increase in air Mn is associated with a 0.57 ng/mL increase in MnB (95% CI -0.04, 1.19). Considering a 90-day exposure window and a cumulative exposure window, a 1 mg-days/m(3) increase in air Mn is associated with a 0.26 (95% CI 0.005, 0.51) and 0.09 (95% CI 0.006, 0.17) ng/mL increase in MnB, respectively. CONCLUSIONS: From this analysis, MnB may begin to act as a biomarker of Mn exposure over longer time periods, or at higher levels of exposure. This novel study design allowed investigation of how MnB relates to different time windows of exposure, representing the most robust Mn exposure assessment in the biomarker literature.
PURPOSE: We sought to understand the time course between exposure to manganese (Mn) and uptake into the blood, to allow a more meaningful interpretation of exposure biomarker data, and to determine the utility of blood as a biomarker of Mn exposure. METHODS: Welder trainees were monitored over the course of a five-quarter training program. Each quarter, trainees gave eight blood samples and had personal air monitoring four times. A mixed model was fit to obtain estimates of airborne exposure by welding type (fixed effect), adjusted for subject (random effect). Considering weekends and days absent as zero exposure, estimated exposures were summed over various exposure windows and related to measured blood manganese (MnB) using a mixed model. RESULTS: A relationship consistent with zero was found between MnB and modeled 1 or 7 days of exposure. After 30 days of preceding exposure, a 1 mg-days/m(3) increase in air Mn is associated with a 0.57 ng/mL increase in MnB (95% CI -0.04, 1.19). Considering a 90-day exposure window and a cumulative exposure window, a 1 mg-days/m(3) increase in air Mn is associated with a 0.26 (95% CI 0.005, 0.51) and 0.09 (95% CI 0.006, 0.17) ng/mL increase in MnB, respectively. CONCLUSIONS: From this analysis, MnB may begin to act as a biomarker of Mn exposure over longer time periods, or at higher levels of exposure. This novel study design allowed investigation of how MnB relates to different time windows of exposure, representing the most robust Mn exposure assessment in the biomarker literature.
Authors: Wisanti Laohaudomchok; Xihong Lin; Robert F Herrick; Shona C Fang; Jennifer M Cavallari; David C Christiani; Marc G Weisskopf Journal: J Occup Environ Med Date: 2011-05 Impact factor: 2.162
Authors: Susan R Criswell; Joel S Perlmutter; John L Huang; Nima Golchin; Hubert P Flores; Angela Hobson; Michael Aschner; Keith M Erikson; Harvey Checkoway; Brad A Racette Journal: Occup Environ Med Date: 2012-03-23 Impact factor: 4.402
Authors: Beate Pesch; Tobias Weiss; Benjamin Kendzia; Jana Henry; Martin Lehnert; Anne Lotz; Evelyn Heinze; Heiko Udo Käfferlein; Rainer Van Gelder; Markus Berges; Jens-Uwe Hahn; Markus Mattenklott; Ewald Punkenburg; Andrea Hartwig; Thomas Brüning Journal: J Expo Sci Environ Epidemiol Date: 2012-02-29 Impact factor: 5.563
Authors: Marissa G Baker; Susan R Criswell; Brad A Racette; Christopher D Simpson; Lianne Sheppard; Harvey Checkoway; Noah S Seixas Journal: Scand J Work Environ Health Date: 2014-11-07 Impact factor: 5.024
Authors: Krishnan Sriram; Gary X Lin; Amy M Jefferson; Jenny R Roberts; Ronnee N Andrews; Michael L Kashon; James M Antonini Journal: Toxicology Date: 2011-11-09 Impact factor: 4.221
Authors: S R Criswell; J S Perlmutter; T O Videen; S M Moerlein; H P Flores; A M Birke; B A Racette Journal: Neurology Date: 2011-04-06 Impact factor: 9.910
Authors: Marissa G Baker; Christopher D Simpson; Bert Stover; Lianne Sheppard; Harvey Checkoway; Brad A Racette; Noah S Seixas Journal: J Occup Environ Hyg Date: 2014 Impact factor: 2.155
Authors: David S Grass; James M Ross; Farnosh Family; Jonathan Barbour; H James Simpson; Drissa Coulibaly; Jennifer Hernandez; Yingdi Chen; Vesna Slavkovich; Yongliang Li; Joseph Graziano; Regina M Santella; Paul Brandt-Rauf; Steven N Chillrud Journal: Environ Res Date: 2010-01 Impact factor: 6.498
Authors: Eric J Ward; David A Edmondson; Mahmoud M Nour; Sandy Snyder; Frank S Rosenthal; Ulrike Dydak Journal: Ann Work Expo Health Date: 2017-12-15 Impact factor: 2.179
Authors: Marissa G Baker; Christopher D Simpson; Yvonne S Lin; Laura M Shireman; Noah Seixas Journal: Ann Work Expo Health Date: 2017-05-01 Impact factor: 2.179
Authors: Marissa G Baker; Yvonne S Lin; Christopher D Simpson; Laura M Shireman; Susan Searles Nielsen; Brad A Racette; Noah Seixas Journal: J Trace Elem Med Biol Date: 2018-11-03 Impact factor: 3.849
Authors: Mechelle M Lewis; Michael R Flynn; Eun-Young Lee; Scott Van Buren; Eric Van Buren; Guangwei Du; Rebecca C Fry; Amy H Herring; Lan Kong; Richard B Mailman; Xuemei Huang Journal: Neurotoxicology Date: 2016-08-24 Impact factor: 4.294
Authors: Dazhe Chen; Kaitlyn G Lawrence; Gregory C Pratt; Mark R Stenzel; Patricia A Stewart; Caroline P Groth; Sudipto Banerjee; Kate Christenbury; Matthew D Curry; W Braxton Jackson; Richard K Kwok; Aaron Blair; Lawrence S Engel; Dale P Sandler Journal: Environ Health Perspect Date: 2022-02-01 Impact factor: 9.031