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Literature DB >> 26588872

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Abstract

Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumourigenesis. It is well-established that the G protein-coupled receptor 55 (GPR55) is the specific receptor for LPI. Several investigations have demonstrated that the signalling pathways activated by LPI through its receptor GPR55 play a pivotal role in different cancer type. This review focuses on the role of the LPI/GPR55 axis, in particular with regards to its pharmacological potential therapeutic exploitation. Crown

Entities: Chemical

Keywords: ABC transporters; Cancer; Cannabidiol; G protein-coupled receptor 55; LPI

Mesh：

Substances：

Year: 2015 PMID： 26588872 DOI： 10.1016/j.jbior.2015.10.003

Source DB: PubMed Journal: Adv Biol Regul ISSN： 2212-4926

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Cited

25 in total

Review 1. Phospholipid regulation of the nuclear receptor superfamily.

Authors: Mark K Crowder; Corey D Seacrist; Raymond D Blind
Journal: Adv Biol Regul Date: 2016-10-29

2. GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

Authors: Solomiia Korchynska; Mirjam I Lutz; Erzsébet Borók; Johannes Pammer; Valentina Cinquina; Nataliya Fedirko; Andrew J Irving; Ken Mackie; Tibor Harkany; Erik Keimpema
Journal: JCI Insight Date: 2019-02-21

3. Endocannabinoid-Binding Receptors as Drug Targets.

Authors: María Gómez-Cañas; Carmen Rodríguez-Cueto; Valentina Satta; Inés Hernández-Fisac; Elisa Navarro; Javier Fernández-Ruiz
Journal: Methods Mol Biol Date: 2023

4. Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.

Authors: Hager Tarek H Ismail; Manar AbdelMageed; Gudrun Lindmark; Marie-Louise Hammarström; Sten Hammarström; Basel Sitohy
Journal: Int J Mol Sci Date: 2022-04-20 Impact factor: 6.208

5. Targeting CB₁ and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.

Authors: Eva Martínez-Pinilla; David Aguinaga; Gemma Navarro; Alberto J Rico; Julen Oyarzábal; Juan A Sánchez-Arias; José Luis Lanciego; Rafael Franco
Journal: Mol Neurobiol Date: 2019-01-28 Impact factor: 5.590

6. G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.

Authors: Carina Hasenoehrl; David Feuersinger; Eva M Sturm; Thomas Bärnthaler; Ellen Heitzer; Ricarda Graf; Magdalena Grill; Martin Pichler; Stephan Beck; Lee Butcher; Dominique Thomas; Nerea Ferreirós; Rufina Schuligoi; Caroline Schweiger; Johannes Haybaeck; Rudolf Schicho
Journal: Int J Cancer Date: 2017-09-21 Impact factor: 7.396

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Review 1. Phospholipid regulation of the nuclear receptor superfamily.

2. GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

3. Endocannabinoid-Binding Receptors as Drug Targets.

4. Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.

5. Targeting CB₁ and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.

6. G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.

Review 7. Lysophosphatidylinositol Signalling and Metabolic Diseases.

Review 8. Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents.

9. Analysis of glycero-lysophospholipids in gastric cancerous ascites.

Review 10. Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms.

Role of the lysophosphatidylinositol/GPR55 axis in cancer.

Review 1. Phospholipid regulation of the nuclear receptor superfamily.

2. GPR55 controls functional differentiation of self-renewing epithelial progenitors for salivation.

3. Endocannabinoid-Binding Receptors as Drug Targets.

4. Prognostic Significance of GPR55 mRNA Expression in Colon Cancer.

5. Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.

6. G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.

Review 7. Lysophosphatidylinositol Signalling and Metabolic Diseases.

Review 8. Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents.

9. Analysis of glycero-lysophospholipids in gastric cancerous ascites.

Review 10. Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms.

5. Targeting CB₁ and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease.