| Literature DB >> 26588774 |
Aude de Gassart1, Fabio Martinon2.
Abstract
How inflammatory caspases trigger pyroptotic cell death is mostly unexplained. In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.Entities:
Keywords: Pyroptosis; caspase-11; danger signals; inflammation
Mesh:
Substances:
Year: 2015 PMID: 26588774 DOI: 10.1016/j.immuni.2015.10.024
Source DB: PubMed Journal: Immunity ISSN: 1074-7613 Impact factor: 31.745