Miklos Z Molnar1, Vanessa Ravel, Elani Streja, Csaba P Kovesdy, Rajnish Mehrotra, Kamyar Kalantar-Zadeh. 1. 1 Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN. 2 Division of Nephrology, University of California, Irvine, CA. 3 Nephrology Section, Memphis Veterans Affairs Medical Center, Memphis, TN. 4 Department of Medicine, Division of Nephrology, Harborview Medical Center and Kidney Research Institute, University of Washington, Seattle, WA. 5 Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA.
Abstract
BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score-matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score-matched HHD and KTx patients at baseline were 54 ± 15 years and 54 ± 14 years, 65% were men (both groups), 70% and 72% of patients were whites, and 19% were African American (both groups), respectively. Over 5 years of follow-up, HHD patients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95% confidence interval [95% CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHD patients had higher mortality risk (HR, 4.21; 95% CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTx patients (HR, 1.62; 95% CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHD patients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.
BACKGROUND: Previous studies have indicated that patients on maintenance hemodialysis have worse survival compared with kidney transplant (KTx) recipients. However, none of these studies have compared mortality of the US patients using alternative dialysis modalities such as home hemodialysis (HHD) with KTx recipients. METHODS: Comparing patients who started HHD with those who received kidney transplantation in the United States between 2007 and 2011, we created a 1:1 propensity score-matched cohort of 4000 patients and examined the association between treatment modality and all-cause mortality using Cox proportional hazard models. RESULTS: The mean ± SD age of the propensity score-matched HHD and KTxpatients at baseline were 54 ± 15 years and 54 ± 14 years, 65% were men (both groups), 70% and 72% of patients were whites, and 19% were African American (both groups), respectively. Over 5 years of follow-up, HHDpatients had 4 times higher mortality risk compared with KTx recipients in the entire patient population (hazard ratio [HR], 4.06; 95% confidence interval [95% CI], 3.27-5.04); total event number, 411), and similar difference was found across each race stratum. However, during the first year of therapy, although the white HHDpatients had higher mortality risk (HR, 4.21; 95% CI, 3.10-5.73; total event number, 332) compared with their KTx counterparts, there was no significant difference in mortality risk between African American HHD and KTxpatients (HR, 1.62; 95% CI, 0.77-3.39; total event number, 55). This result was consistent across different types of kidney donors. CONCLUSIONS: The HHDpatients appear to have 4 times higher mortality compared with KTx recipients regardless of the type of kidney donor. Further studies are needed to understand the reasons underlying racial differenes during the first year of therapy.
Authors: Nazanin Noori; Csaba P Kovesdy; Ramanath Dukkipati; Usama Feroze; Miklos Z Molnar; Rachelle Bross; Allen R Nissenson; Joel D Kopple; Keith C Norris; Kamyar Kalantar-Zadeh Journal: Am J Nephrol Date: 2011-02-04 Impact factor: 3.754
Authors: Andras Szentkiralyi; Maria E Czira; Miklos Z Molnar; Csaba P Kovesdy; Adam Remport; Lilla Szeifert; Eszter P Vamos; Janos Juhasz; Csilla Z Turanyi; Istvan Mucsi; Marta Novak Journal: Sleep Med Date: 2011-02-02 Impact factor: 3.492
Authors: Bruce F Culleton; Michael Walsh; Scott W Klarenbach; Garth Mortis; Narine Scott-Douglas; Robert R Quinn; Marcello Tonelli; Sarah Donnelly; Matthias G Friedrich; Andreas Kumar; Houman Mahallati; Brenda R Hemmelgarn; Braden J Manns Journal: JAMA Date: 2007-09-19 Impact factor: 56.272
Authors: Michael Walsh; Braden J Manns; Scott Klarenbach; Marcello Tonelli; Brenda Hemmelgarn; Bruce Culleton Journal: Hemodial Int Date: 2009-12-22 Impact factor: 1.812
Authors: Kamyar Kalantar-Zadeh; Csaba P Kovesdy; Elani Streja; Connie M Rhee; Melissa Soohoo; Joline L T Chen; Miklos Z Molnar; Yoshitsugu Obi; Daniel Gillen; Danh V Nguyen; Keith C Norris; John J Sim; Steve S Jacobsen Journal: Nephrol Dial Transplant Date: 2017-04-01 Impact factor: 5.992
Authors: Paula Rebello Bicalho; Lúcio R Requião-Moura; Érika Ferraz Arruda; Rogerio Chinen; Luciana Mello; Ana Paula F Bertocchi; Erika Lamkowski Naka; Eduardo José Tonato; Alvaro Pacheco-Silva Journal: Biomed Res Int Date: 2019-04-02 Impact factor: 3.411