Takuro Kubozono1, Mitsuru Ohishi1. 1. Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Abstract
BACKGROUND: Hypertension is strongly associated with cardiovascular disease. It has been reported that arterial stiffness is related to cardiovascular mortality and morbidity in hypertensive patients and that the physiological evaluation of arterial stiffness may assist clinicians in the early detection of atherosclerosis. SUMMARY: It has been demonstrated that increased arterial stiffness is an independent predictor of cardiovascular disease, including stroke. Arterial stiffness is associated with structural changes in the brain. However, the stiffness responses of muscular arteries are different from those of elastic arteries, and so the impact of arterial stiffness and the conclusions to be drawn may be different depending on the region in which the measurement is taken. KEY MESSAGES: In this review, we summarize the current literature describing the association between arterial stiffness, including carotid-femoral and brachial-ankle pulse wave velocity and cardio-ankle vascular index, and cardiovascular disease, specifically stroke. We discuss the utility and prognostic significance of regional arterial stiffness measurements.
BACKGROUND:Hypertension is strongly associated with cardiovascular disease. It has been reported that arterial stiffness is related to cardiovascular mortality and morbidity in hypertensivepatients and that the physiological evaluation of arterial stiffness may assist clinicians in the early detection of atherosclerosis. SUMMARY: It has been demonstrated that increased arterial stiffness is an independent predictor of cardiovascular disease, including stroke. Arterial stiffness is associated with structural changes in the brain. However, the stiffness responses of muscular arteries are different from those of elastic arteries, and so the impact of arterial stiffness and the conclusions to be drawn may be different depending on the region in which the measurement is taken. KEY MESSAGES: In this review, we summarize the current literature describing the association between arterial stiffness, including carotid-femoral and brachial-ankle pulse wave velocity and cardio-ankle vascular index, and cardiovascular disease, specifically stroke. We discuss the utility and prognostic significance of regional arterial stiffness measurements.
Authors: I Narita; M Okada; S Omori; M Nagai; N Sawanaka; D Kondo; S Goto; H Shimada; T Shimotori; M Arakawa; F Gejyo Journal: Hypertens Res Date: 2001-03 Impact factor: 3.872
Authors: Y Shimizu; T Itoh; H Hougaku; Y Nagai; H Hashimoto; M Sakaguchi; N Handa; K Kitagawa; M Matsumoto; M Hori Journal: Hypertens Res Date: 2001-01 Impact factor: 3.872
Authors: Léon H G Henskens; Abraham A Kroon; Robert J van Oostenbrugge; Ed H B M Gronenschild; Monique M J J Fuss-Lejeune; Paul A M Hofman; Jan Lodder; Peter W de Leeuw Journal: Hypertension Date: 2008-10-13 Impact factor: 10.190