Literature DB >> 26587329

ISG15: A double edged sword in cancer.

Shyamal D Desai1.   

Abstract

Interferon-Stimulated Gene 15 (ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.

Entities:  

Keywords:  ISG15; cancer; immune system; immunostimulatory cytokine; ubiquitin/26S proteasome

Year:  2015        PMID： 26587329      PMCID： PMC4635879          DOI： 10.1080/2162402X.2015.1052935

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Basic Medical Research Award. The ubiquitin system.

Authors:  A Hershko; A Ciechanover; A Varshavsky
Journal:  Nat Med       Date:  2000-10       Impact factor: 53.440

Review 2.  Ubiquitin-like proteins.

Authors:  Annemarthe G van der Veen; Hidde L Ploegh
Journal:  Annu Rev Biochem       Date:  2012-03-09       Impact factor: 23.643

3.  Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

Authors:  A L Haas; P Ahrens; P M Bright; H Ankel
Journal:  J Biol Chem       Date:  1987-08-15       Impact factor: 5.157

4.  ISG15 disrupts cytoskeletal architecture and promotes motility in human breast cancer cells.

Authors:  Shyamal D Desai; Ryan E Reed; Julian Burks; Laurence M Wood; Ashok K Pullikuth; Arthur L Haas; Leroy F Liu; Jerome W Breslin; Sally Meiners; Surendran Sankar
Journal:  Exp Biol Med (Maywood)       Date:  2011-12-20

5.  Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

Authors:  Shyamal D Desai; Arthur L Haas; Laurence M Wood; Yu-Chen Tsai; Sidney Pestka; Eric H Rubin; Ahamed Saleem; Alam Nur-E-Kamal; Leroy F Liu
Journal:  Cancer Res       Date:  2006-01-15       Impact factor: 12.701

6.  ISG15 as a novel tumor biomarker for drug sensitivity.

Authors:  Shyamal D Desai; Laurence M Wood; Yu-Chen Tsai; Tao-Shih Hsieh; Jeffrey R Marks; Georgia L Scott; Beppino C Giovanella; Leroy F Liu
Journal:  Mol Cancer Ther       Date:  2008-06       Impact factor: 6.261

7.  ISGylation governs the oncogenic function of Ki-Ras in breast cancer.

Authors:  J Burks; R E Reed; S D Desai
Journal:  Oncogene       Date:  2013-01-14       Impact factor: 9.867

8.  Immunoregulatory properties of ISG15, an interferon-induced cytokine.

Authors:  J D'Cunha; E Knight; A L Haas; R L Truitt; E C Borden
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

9.  Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective.

Authors:  Julian Burks; Ryan E Reed; Shyamal D Desai
Journal:  Oncotarget       Date:  2015-03-30

10.  The ubiquitin-like molecule interferon-stimulated gene 15 (ISG15) is a potential prognostic marker in human breast cancer.

Authors:  Nuran Bektas; Erik Noetzel; Jürgen Veeck; Michael F Press; Glen Kristiansen; Amjad Naami; Arndt Hartmann; Arno Dimmler; Matthias W Beckmann; Ruth Knüchel; Peter A Fasching; Edgar Dahl
Journal:  Breast Cancer Res       Date:  2008-07-15       Impact factor: 6.466
  10 in total
  18 in total

Review 1.  Regulation of mitophagy by the ubiquitin pathway in neurodegenerative diseases.

Authors:  Shyamal Desai; Meredith Juncker; Catherine Kim
Journal:  Exp Biol Med (Maywood)       Date:  2018-01-09

2.  Increased ISGylation in Cases of TBI-Exposed ALS Veterans.

Authors:  Joshua Schwartzenburg; Meredith Juncker; Ryan Reed; Shyamal Desai
Journal:  J Neuropathol Exp Neurol       Date:  2019-03-01       Impact factor: 3.685

3.  Deleting key autophagy elongation proteins induces acquirement of tumor-associated phenotypes via ISG15.

Authors:  EunBin Kong; Hag Dong Kim; Joon Kim
Journal:  Cell Death Differ       Date:  2020-03-03       Impact factor: 15.828

4.  Loss of TRIM29 suppresses cancer stem cell-like characteristics of PDACs via accelerating ISG15 degradation.

Authors:  Jia Sun; Jing Yan; Huai-Yu Qiao; Fu-Ying Zhao; Chao Li; Jing-Yi Jiang; Bao-Qin Liu; Xiao-Na Meng; Hua-Qin Wang
Journal:  Oncogene       Date:  2019-09-09       Impact factor: 9.867

Review 5.  Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.

Authors:  Lisa Maria Mustachio; Yun Lu; Masanori Kawakami; Jason Roszik; Sarah J Freemantle; Xi Liu; Ethan Dmitrovsky
Journal:  Cancer Res       Date:  2018-01-17       Impact factor: 12.701

Review 6.  Post-translational add-ons mark the path in exosomal protein sorting.

Authors:  Olga Moreno-Gonzalo; Irene Fernandez-Delgado; Francisco Sanchez-Madrid
Journal:  Cell Mol Life Sci       Date:  2017-10-27       Impact factor: 9.261

7.  The ISG15-specific protease USP18 regulates stability of PTEN.

Authors:  Lisa Maria Mustachio; Masanori Kawakami; Yun Lu; Jaime Rodriguez-Canales; Barbara Mino; Carmen Behrens; Ignacio Wistuba; Neus Bota-Rabassedas; Jun Yu; J Jack Lee; Jason Roszik; Lin Zheng; Xi Liu; Sarah J Freemantle; Ethan Dmitrovsky
Journal:  Oncotarget       Date:  2017-01-03

8.  ISG15 induces ESRP1 to inhibit lung adenocarcinoma progression.

Authors:  Tongyuan Qu; Wenshuai Zhang; Lisha Qi; Lu Cao; Changxu Liu; Qiujuan Huang; Guangning Li; Lingmei Li; Yalei Wang; Qianru Guo; Yuhong Guo; Danyang Ren; Yanan Gao; Jinpeng Wang; Bin Meng; Bin Zhang; Wenfeng Cao
Journal:  Cell Death Dis       Date:  2020-07-02       Impact factor: 8.469

9.  Interferon-stimulated gene 15 in hepatitis B-related liver diseases.

Authors:  Nghiem Xuan Hoan; Hoang Van Tong; Dao Phuong Giang; Nguyen Linh Toan; Christian G Meyer; C-Thomas Bock; Peter G Kremsner; Le Huu Song; Thirumalaisamy P Velavan
Journal:  Oncotarget       Date:  2016-10-18

10.  Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer.

Authors:  Katerin Rojas L; Lucía Trilla-Fuertes; Angelo Gámez-Pozo; Cristina Chiva; Juan Sepúlveda; Luis Manso; Guillermo Prado-Vázquez; Andrea Zapater-Moros; Rocío López-Vacas; María Ferrer-Gómez; César Mendiola; Enrique Espinosa; Eduard Sabidó; Eva Ciruelos; Juan Ángel Fresno Vara
Journal:  Ecancermedicalscience       Date:  2019-01-15
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