| Literature DB >> 26586619 |
Daisuke Mikami1, Hideyuki Kurihara2, Momoka Ono3, Sang Moo Kim4, Koretaro Takahashi3.
Abstract
A novel bromophenol, n-butyl 2,3-dibromo-4,5-dihydroxybenzyl ether, and known bromophenols were isolated from Rhodomelaceae algae as glucose 6-phosphate dehydrogenase (G6PD) inhibitors. Among them, bromophenol dimers showed stronger inhibitory activity against Leuconostoc mesenteroides and Saccharomyces cerevisiae G6PDs than the corresponding monomers. The dibenzyl ether-type dimers had lower IC50 values than the diarylmethane-type dimers against L. mesenteroides G6PD among the bromophenols examined. In contrast, the inhibitory activities of diarylmethane-type dimers against S. cerevisiae G6PD were stronger than those of dibenzyl ether-type dimers. Especially, 3-bromo-2-(2,3-dibromo-4,5-dihydroxybenzyl)-4,5-dihydroxybenzyl methyl ether selectively inhibited S. cerevisiae G6PD compared to L. mesenteroides G6PD.Entities:
Keywords: Alga; Bromophenol; Glucose 6-phosphate dehydrogenase; Inhibition; Polyphenol
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Year: 2015 PMID： 26586619 DOI： 10.1016/j.fitote.2015.11.002
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882