Literature DB >> 26586400

Aberrant regulation of miR-15b in human malignant tumors and its effects on the hallmarks of cancer.

Ci Zhao1, Guanyu Wang1, Yuanyuan Zhu1, Xiaobo Li2, Feihu Yan1, Chunhui Zhang1, Xiaoyi Huang3, Yanqiao Zhang4.   

Abstract

MicroRNAs encoded by the miR-15b/16-2 cluster act as tumor suppressors. Aberrant regulation of miR-15b in human malignant tumors is reportedly involved in cancer development, contributing to cell death, reduced proliferation, angiogenesis and metastasis resistance, metabolism reprogramming, genome instability, and tumor-associated inflammation. In this review, we summarize the mechanisms involved in regulating miR-15b expression in mammalian tumors and discuss the effects of miR-15b dysregulation on the hallmarks of cancer and highlight its role as a potentially valuable target for future cancer therapeutic strategies.

Entities:  

Keywords:  Angiogenesis and metastasis; Metabolism; MiR-15b; MicroRNAs

Mesh：

Substances：

Year:  2015        PMID： 26586400     DOI： 10.1007/s13277-015-4269-2

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  59 in total

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Authors:  Hongping Xia; Yanting Qi; Samuel S Ng; Xiaona Chen; Shen Chen; Marong Fang; Dan Li; Yu Zhao; Ruiguang Ge; Guo Li; Yangchao Chen; Ming-Liang He; Hsiang-fu Kung; Lihui Lai; Marie C Lin
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Review 3.  Dysregulated MicroRNA Expression Profiles and Potential Cellular, Circulating and Polymorphic Biomarkers in Non-Hodgkin Lymphoma.

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6.  miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo.

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7.  miR-15b-5p facilitates the tumorigenicity by targeting RECK and predicts tumour recurrence in prostate cancer.

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8.  Bioinformatics analysis of microRNA expression between patients with and without latent tuberculosis infections.

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10.  Comprehensive Analysis of Correlations in the Expression of miRNA Genes and Immune Checkpoint Genes in Bladder Cancer Cells.

Authors:  Przemysław A Stempor; Dror Avni; Raya Leibowitz; Yechezkel Sidi; Maria Stępień; Tomasz Dzieciątkowski; Paula Dobosz
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  10 in total

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