Hai-Bo Ge1, Shi Chen2. 1. Department of Tuberculosis, Nanjing Chest Hospital, Medicine School of Southeast University, Nanjing 210029, PR China. Electronic address: submanuscript2014@yeah.net. 2. Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, PR China.
Abstract
OBJECTIVE: A meta-analysis was performed to determine the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility. METHODS: Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility. RESULTS: A total of 1916 cases and 2194 controls in 10 studies were pooled together for evaluation of the overall association between P2X7-1513A/C polymorphism and susceptibility of pulmonary tuberculosis. Allele model (A vs. C: p=0.15; OR=0.86, 95% CI=0.69-1.06), homozygous model (AA vs. CC: p=0.22; OR=0.78, 95% CI=0.53-1.16), and heterozygous model (AC vs. CC: p=0.23; OR=0.80, 95% CI=0.56-1.15) did not show decreased risk of developing pulmonary tuberculosis. Similarly, dominant model (AA+AC vs. CC: p=0.19; OR=0.80, 95% CI=0.56-1.12) and recessive model (AA vs. AC+CC: p=0.21; OR=0.85, 95% CI=0.66-1.10) failed to show decreased risk of developing pulmonary tuberculosis. In Indians, allele model (A vs. C: p=0.0006; OR=0.69, 95% CI=0.55-0.85), and recessive model (AA vs. AC+CC: p=0.0003; OR=0.62, 95% CI=0.48-0.80) indicated significant association between P2X7-1513A/C polymorphism and susceptibility to pulmonary tuberculosis. CONCLUSIONS: Our pooled data suggest a association between P2X7-1513A/C polymorphism and the prevalence of pulmonary tuberculosis among Indian populations.
OBJECTIVE: A meta-analysis was performed to determine the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility. METHODS: Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility. RESULTS: A total of 1916 cases and 2194 controls in 10 studies were pooled together for evaluation of the overall association between P2X7-1513A/C polymorphism and susceptibility of pulmonary tuberculosis. Allele model (A vs. C: p=0.15; OR=0.86, 95% CI=0.69-1.06), homozygous model (AA vs. CC: p=0.22; OR=0.78, 95% CI=0.53-1.16), and heterozygous model (AC vs. CC: p=0.23; OR=0.80, 95% CI=0.56-1.15) did not show decreased risk of developing pulmonary tuberculosis. Similarly, dominant model (AA+AC vs. CC: p=0.19; OR=0.80, 95% CI=0.56-1.12) and recessive model (AA vs. AC+CC: p=0.21; OR=0.85, 95% CI=0.66-1.10) failed to show decreased risk of developing pulmonary tuberculosis. In Indians, allele model (A vs. C: p=0.0006; OR=0.69, 95% CI=0.55-0.85), and recessive model (AA vs. AC+CC: p=0.0003; OR=0.62, 95% CI=0.48-0.80) indicated significant association between P2X7-1513A/C polymorphism and susceptibility to pulmonary tuberculosis. CONCLUSIONS: Our pooled data suggest a association between P2X7-1513A/C polymorphism and the prevalence of pulmonary tuberculosis among Indian populations.
Authors: Samuel Halstrom; Catherine L Cherry; Michael Black; Rachel Thomson; Hayley Goullee; Svetlana Baltic; Richard Allcock; Suzanna E L Temple; Patricia Price Journal: Immunogenetics Date: 2017-02-23 Impact factor: 2.846