Literature DB >> 26585276

Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin.

Benjamin P Martin1, Elena Vasilieva1, Cynthia M Dupureur1, Christopher D Spilling2.   

Abstract

New monocyclic phosphate, phosphonate and difluorophosphonate analogs of the natural AChE inhibitor cyclophostin were synthesized and their activity toward human AChE examined. Surprisingly, the phosphate, phosphonate, and difluorophosphonate analogs all showed diminished activity when compared with the natural product.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Acetyl cholinesterase; Cyclic phosphate; Cyclic phosphonate; Difluorophosphonate; Inhibition

Mesh：

Substances：

Year:  2015        PMID： 26585276     DOI： 10.1016/j.bmc.2015.10.044

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  2 in total

1.  Cyclipostins and Cyclophostin analogs as promising compounds in the fight against tuberculosis.

Authors:  Phuong Chi Nguyen; Vincent Delorme; Anaïs Bénarouche; Benjamin P Martin; Rishi Paudel; Giri R Gnawali; Abdeldjalil Madani; Rémy Puppo; Valérie Landry; Laurent Kremer; Priscille Brodin; Christopher D Spilling; Jean-François Cavalier; Stéphane Canaan
Journal:  Sci Rep       Date:  2017-09-18       Impact factor: 4.379

2.  Aryloxy Diester Phosphonamidate Prodrugs of Phosphoantigens (ProPAgens) as Potent Activators of Vγ9/Vδ2 T-Cell Immune Responses.

Authors:  Hachemi Kadri; Taher E Taher; Qin Xu; Maria Sharif; Elizabeth Ashby; Richard T Bryan; Benjamin E Willcox; Youcef Mehellou
Journal:  J Med Chem       Date:  2020-09-29       Impact factor: 7.446
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.