José E Muñoz-Negro1, Inmaculada Ibanez-Casas2, Enrique de Portugal3, Susana Ochoa4, Montserrat Dolz4, Josep M Haro4, Miguel Ruiz-Veguilla5, Juan de Dios Luna Del Castillo6, Jorge A Cervilla7. 1. Mental Health Unit, Granada University Hospital, Granada, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Psychiatry, University of Granada, Spain. 2. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Psychiatry, University of Granada, Spain. 3. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Gregorio Marañón Hospital, Madrid, Spain. 4. Parc Sanitari Sant Joan de Déu, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Sant Boi de Llobregat, Barcelona, Spain. 5. Mental Health Unit, Virgen del Rocío University Hospital, Sevilla, Spain. 6. Facultad de Medicina, Universidad de Granada, Spain. 7. Mental Health Unit, Granada University Hospital, Granada, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Department of Psychiatry, University of Granada, Spain. Electronic address: jcervilla@ugr.es.
Abstract
INTRODUCTION: Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS: 1. To study the psychopathological dimensions of the psychosis spectrum; 2. to explore the association between psychotic dimensions and categorical diagnoses; 3. to compare the different psychotic disorders from a psychopathological and functional point of view. MATERIAL AND METHODS: This is an observational study utilizing a sample of some 550 patients with a psychotic disorder. 373 participants had a diagnosis of schizophrenia, 137 had delusional disorder and 40 with a diagnosis of schizoaffective disorder. The PANSS was used to elicit psychopathology and global functioning was ascertained using the GAF measure. Both exploratory and confirmatory factor analyses of the PANSS items were performed to extract psychopathological dimensions. Associations between diagnostic categories and dimensions were subsequently studied using ANOVA tests. RESULTS: 5 dimensions - manic, negative symptoms, depression, positive symptoms and cognitive - emerged. The model explained 57.27% of the total variance. The dimensional model was useful to explained differences and similarities between all three psychosis spectrum categories. The potential clinical usefulness of this dimensional model within and between clinical psychosis spectrum categories is discussed.
INTRODUCTION: Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS: 1. To study the psychopathological dimensions of the psychosis spectrum; 2. to explore the association between psychotic dimensions and categorical diagnoses; 3. to compare the different psychotic disorders from a psychopathological and functional point of view. MATERIAL AND METHODS: This is an observational study utilizing a sample of some 550 patients with a psychotic disorder. 373 participants had a diagnosis of schizophrenia, 137 had delusional disorder and 40 with a diagnosis of schizoaffective disorder. The PANSS was used to elicit psychopathology and global functioning was ascertained using the GAF measure. Both exploratory and confirmatory factor analyses of the PANSS items were performed to extract psychopathological dimensions. Associations between diagnostic categories and dimensions were subsequently studied using ANOVA tests. RESULTS: 5 dimensions - manic, negative symptoms, depression, positive symptoms and cognitive - emerged. The model explained 57.27% of the total variance. The dimensional model was useful to explained differences and similarities between all three psychosis spectrum categories. The potential clinical usefulness of this dimensional model within and between clinical psychosis spectrum categories is discussed.
Authors: José Eduardo Muñoz-Negro; Inmaculada Ibáñez-Casas; Enrique de Portugal; Vanessa Lozano-Gutiérrez; Rafael Martínez-Leal; Jorge A Cervilla Journal: Can J Psychiatry Date: 2017-06-08 Impact factor: 4.356
Authors: Stephanie M Y Wong; Y N Suen; Charlotte W C Wong; Sherry K W Chan; Christy L M Hui; W C Chang; Edwin H M Lee; Calvin P W Cheng; Garrett C L Ho; Gladys Goh Lo; Eric Y L Leung; Paul K M Au Yeung; Sirong Chen; William G Honer; Henry K F Mak; P C Sham; Peter J McKenna; Edith Pomarol-Clotet; Mattia Veronese; Oliver D Howes; Eric Y H Chen Journal: Psychopharmacology (Berl) Date: 2022-02-25 Impact factor: 4.530
Authors: Line Widing; Carmen Simonsen; Camilla B Flaaten; Beathe Haatveit; Ruth Kristine Vik; Kristin F Wold; Gina Åsbø; Torill Ueland; Ingrid Melle Journal: Front Psychiatry Date: 2020-11-12 Impact factor: 4.157
Authors: Alexandre González-Rodríguez; Mary V Seeman; Eduard Izquierdo; Mentxu Natividad; Armand Guàrdia; Eloïsa Román; José A Monreal Journal: Int J Environ Res Public Health Date: 2022-06-28 Impact factor: 4.614