Literature DB >> 26585195

Methods for studying human organogenesis.

Gerald Cunha1, Maya Overland2, Yi Li2, Mei Cao2, Joel Shen2, Adriane Sinclair2, Laurence Baskin2.   

Abstract

This review details methods for utilizing D & C suction abortus specimens as a source of human fetal organs to study the morphogenetic and molecular mechanisms of human fetal organ development. By this means it is possible to design experiments elucidating the molecular mechanisms of human fetal organ development and to compare and contrast human developmental mechanisms with that of laboratory animals. Finally human fetal organs can be grown in vivo as grafts to athymic mice, thus allowing ethical analysis of potential adverse effects of environmental toxicants.
Copyright © 2015 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Human development; Internal genitalia; Male and female external genitalia

Mesh：

Year:  2015        PMID： 26585195      PMCID： PMC4866906          DOI： 10.1016/j.diff.2015.10.005

Source DB:  PubMed          Journal:  Differentiation        ISSN： 0301-4681            Impact factor:   3.880


  40 in total

1.  Development of the vagina in the human fetus.

Authors:  A K Koff
Journal:  Contrib Embryol       Date:  1933-09

Review 2.  Bisphenol A and human health: a review of the literature.

Authors:  Johanna R Rochester
Journal:  Reprod Toxicol       Date:  2013-08-30       Impact factor: 3.143

3.  Improving the accuracy of fetal foot length to confirm gestational duration.

Authors:  Eleanor A Drey; Mi-Suk Kang; Willi McFarland; Philip D Darney
Journal:  Obstet Gynecol       Date:  2005-04       Impact factor: 7.661

4.  Analysis of the effect of estrogen/androgen perturbation on penile development in transgenic and diethylstilbestrol-treated mice.

Authors:  Sarah D Blaschko; Phitsanu Mahawong; Max Ferretti; Tristan J Cunha; Adriane Sinclair; Hong Wang; Bruce J Schlomer; Gail Risbridger; Laurence S Baskin; Gerald R Cunha
Journal:  Anat Rec (Hoboken)       Date:  2013-05-08       Impact factor: 2.064

5.  Expression of nuclear estrogen-binding sites within developing human fetal vagina and urogenital sinus.

Authors:  O Taguchi; G R Cunha; S J Robboy
Journal:  Am J Anat       Date:  1986-12

Review 6.  Current understanding of hypospadias: relevance of animal models.

Authors:  Gerald R Cunha; Adriane Sinclair; Gail Risbridger; John Hutson; Laurence S Baskin
Journal:  Nat Rev Urol       Date:  2015-04-07       Impact factor: 14.432

7.  Male accessory sex organ morphogenesis is altered by loss of function of Hoxd-13.

Authors:  C A Podlasek; D Duboule; W Bushman
Journal:  Dev Dyn       Date:  1997-04       Impact factor: 3.780

Review 8.  Weight-of-evidence evaluation of reproductive and developmental effects of low doses of bisphenol A.

Authors:  Julie E Goodman; Raphael J Witorsch; Ernest E McConnell; I Glenn Sipes; Tracey M Slayton; Carrie J Yu; Amber M Franz; Lorenz R Rhomberg
Journal:  Crit Rev Toxicol       Date:  2009       Impact factor: 5.635

9.  Noggin is required for normal lobe patterning and ductal budding in the mouse prostate.

Authors:  Crist Cook; Chad M Vezina; Sarah H Allgeier; Aubie Shaw; Min Yu; Richard E Peterson; Wade Bushman
Journal:  Dev Biol       Date:  2007-09-29       Impact factor: 3.582

10.  Canalization of the urethral plate precedes fusion of the urethral folds during male penile urethral development: the double zipper hypothesis.

Authors:  Yi Li; Adriane Sinclair; Mei Cao; Joel Shen; Shweta Choudhry; Sisir Botta; Gerald Cunha; Laurence Baskin
Journal:  J Urol       Date:  2014-10-05       Impact factor: 7.450
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  2 in total

1.  Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation.

Authors:  Dylan Isaacson; Joel Shen; Maya Overland; Yi Li; Adriane Sinclair; Mei Cao; Dylan McCreedy; Meredith Calvert; Todd McDevitt; Gerald R Cunha; Laurence Baskin
Journal:  Differentiation       Date:  2018-09-13       Impact factor: 3.880

2.  Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.

Authors:  Dylan Isaacson; Joel Shen; Mei Cao; Adriane Sinclair; Xuan Yue; Gerald Cunha; Laurence Baskin
Journal:  Differentiation       Date:  2017-09-22       Impact factor: 3.880
  2 in total

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