Literature DB >> 26584913

Cytotoxic and anti-inflammatory activities of phenanthrenes from the medullae of Juncus effusus L.

Wei Ma1, Yue Zhang1, Yun-Yun Ding1, Feng Liu1, Ning Li2.   

Abstract

Bioactivity guided phytochemical investigation of the ethanol extract of the medullae of Juncus effusus resulted in the isolation of two new phenanthrenes, 8-hydroxymethyl-2-hydroxyl-1-methyl-5-vinyl-9,10-dihydrophenanthrene (1), and 5-(1-methoxyethyl)-1-methyl-phenanthren-2,7-diol (2) together with 15 known phenanthrenoids (3-17). The chemical structures of 1 and 2 were established by a combination of spectroscopic techniques. Compounds 1-15 and 17 were evaluated for their cytotoxic activities against five human cancer cell lines (SHSY-5Y, SMMC-7721, HepG-2, Hela and MCF-7) by CCK-8 assay, and their anti-inflammatory activities were also evaluated by inhibition on NO production in LPS-activated murine macrophage RAW 264.7 cells.

Entities:  

Keywords:  Anti-inflammatory activity; Cytotoxicity; Juncaceae; Juncus effuses; Phenanthrene

Mesh：

Substances：

Year:  2015        PMID： 26584913     DOI： 10.1007/s12272-015-0680-x

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  12 in total

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