Literature DB >> 26584641

mTORC2 is a tyrosine kinase.

Xuemin Wang1, Christopher G Proud1.   

Abstract

The mammalian target of rapamycin (mTOR), a protein kinase, is the centre of huge attention due to its importance in intracellular signaling and in health and disease. In their recent study, Yin et al. show that mTOR can regulate signaling through the insulin-like growth factor 1 receptor and that it possesses a new enzymatic activity - the ability to phosphorylate proteins on tyrosine residues.

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Year:  2015        PMID: 26584641      PMCID: PMC4816128          DOI: 10.1038/cr.2015.134

Source DB:  PubMed          Journal:  Cell Res        ISSN: 1001-0602            Impact factor:   25.617


  6 in total

Review 1.  mTOR signaling in growth control and disease.

Authors:  Mathieu Laplante; David M Sabatini
Journal:  Cell       Date:  2012-04-13       Impact factor: 41.582

2.  Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Authors:  Yonghao Yu; Sang-Oh Yoon; George Poulogiannis; Qian Yang; Xiaoju Max Ma; Judit Villén; Neil Kubica; Gregory R Hoffman; Lewis C Cantley; Steven P Gygi; John Blenis
Journal:  Science       Date:  2011-06-10       Impact factor: 47.728

3.  The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

Authors:  Peggy P Hsu; Seong A Kang; Jonathan Rameseder; Yi Zhang; Kathleen A Ottina; Daniel Lim; Timothy R Peterson; Yongmun Choi; Nathanael S Gray; Michael B Yaffe; Jarrod A Marto; David M Sabatini
Journal:  Science       Date:  2011-06-10       Impact factor: 47.728

4.  mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

Authors:  Sung Jin Kim; Michael A DeStefano; Won Jun Oh; Chang-chih Wu; Nicole M Vega-Cotto; Monica Finlan; Dou Liu; Bing Su; Estela Jacinto
Journal:  Mol Cell       Date:  2012-11-08       Impact factor: 17.970

5.  Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB.

Authors:  Dos D Sarbassov; Siraj M Ali; Shomit Sengupta; Joon-Ho Sheen; Peggy P Hsu; Alex F Bagley; Andrew L Markhard; David M Sabatini
Journal:  Mol Cell       Date:  2006-04-06       Impact factor: 17.970

6.  mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR.

Authors:  Yancun Yin; Hui Hua; Minjing Li; Shu Liu; Qingbin Kong; Ting Shao; Jiao Wang; Yuanming Luo; Qian Wang; Ting Luo; Yangfu Jiang
Journal:  Cell Res       Date:  2015-11-20       Impact factor: 25.617

  6 in total
  8 in total

1.  Mammalian target of rapamycin complex 2 regulates muscle glucose uptake during exercise in mice.

Authors:  Maximilian Kleinert; Benjamin L Parker; Andreas M Fritzen; Jonas R Knudsen; Thomas E Jensen; Rasmus Kjøbsted; Lykke Sylow; Markus Ruegg; David E James; Erik A Richter
Journal:  J Physiol       Date:  2017-06-11       Impact factor: 5.182

Review 2.  Synthesis and production of steviol glycosides: recent research trends and perspectives.

Authors:  Marta Libik-Konieczny; Ewa Capecka; Monika Tuleja; Robert Konieczny
Journal:  Appl Microbiol Biotechnol       Date:  2021-04-29       Impact factor: 4.813

3.  The associations of DNA methylation alterations in oxidative stress-related genes with cancer incidence and mortality outcomes: a population-based cohort study.

Authors:  Xīn Gào; Yan Zhang; Barbara Burwinkel; Yang Xuan; Bernd Holleczek; Hermann Brenner; Ben Schöttker
Journal:  Clin Epigenetics       Date:  2019-01-24       Impact factor: 6.551

4.  mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma.

Authors:  Jun Zhang; Lin Jia; Tengfei Liu; Yim Ling Yip; Wing Chung Tang; Weitao Lin; Wen Deng; Kwok Wai Lo; Chanping You; Maria Li Lung; Hong Lok Lung; Annie Lai-Man Cheung; Sai Wah Tsao; Chi Man Tsang
Journal:  Oncogene       Date:  2019-02-11       Impact factor: 9.867

5.  Identification of dysfunctional human-dog dyads through dog ownership histories.

Authors:  Rute Canejo-Teixeira; Isabel Neto; Luís V Baptista; Maria Manuela Rodeia Espada Niza
Journal:  Open Vet J       Date:  2019-05-10

Review 6.  Insulin-like growth factor-1 deficiency and metabolic syndrome.

Authors:  G A Aguirre; J Rodríguez De Ita; R G de la Garza; I Castilla-Cortazar
Journal:  J Transl Med       Date:  2016-01-06       Impact factor: 5.531

Review 7.  mTOR Inhibitors in Advanced Biliary Tract Cancers.

Authors:  Chao-En Wu; Ming-Huang Chen; Chun-Nan Yeh
Journal:  Int J Mol Sci       Date:  2019-01-24       Impact factor: 5.923

Review 8.  Chemotherapy Resistance: Role of Mitochondrial and Autophagic Components.

Authors:  Entaz Bahar; Sun-Young Han; Ji-Ye Kim; Hyonok Yoon
Journal:  Cancers (Basel)       Date:  2022-03-12       Impact factor: 6.639

  8 in total

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