Cristina Hernán García1, Lourdes Moreno Cea2, Virginia Fernández Espinilla2, Gema Ruiz Lopez Del Prado2, Socorro Fernández Arribas3, Irene Andrés García2, Verónica Rubio2, Silvan Vesenbeckh4, José María Eiros Bouza5. 1. Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, España. Electronic address: cristinahernang@gmail.com. 2. Servicio de Medicina Preventiva y Salud Publica, Hospital Clínico Universitario de Valladolid, Valladolid, España. 3. Servicio de Epidemiología, Dirección General de Salud Pública, Consejería de Sanidad, Valladolid, España. 4. Department of Respiratory Medicine, HELIOS Klinikum Emil von Behring, Berlín, Alemania. 5. Hospital Clínico Universitario de Valladolid, Valladolid, España.
Abstract
BACKGROUND: Tuberculosis (TB) remains a major public health problem. In 2013, 9 million new cases of active TB were estimated globally and the proportion of reported new cases with multi-drug resistance (MDR) was 3.5%. METHODS: Contact tracing of a case of pulmonary tuberculosis was performed in a Bolivian patient. Diagnostic tests were performed according to national and local protocols. RESULTS: An outbreak of tuberculosis in an immigrant community was detected, with 5 cases originating from one index case. Genotyping and drug susceptibility testing of the sputum samples determined Mycobacterium tuberculosis resistant to isoniazid (KatG-msp unmutated/inhA 5RBS CT). Active case finding revealed a total of 39 contacts with an incidence of latent infection of 71.43%. CONCLUSIONS: The present study confirms the importance of active case finding through contact tracing as well as rapid laboratory diagnosis to achieve improvements in early detection of TB. Early diagnosis of the patient, compliance with appropriate treatment protocols and monitoring of drug resistance are considered essential for the prevention and control of TB.
BACKGROUND:Tuberculosis (TB) remains a major public health problem. In 2013, 9 million new cases of active TB were estimated globally and the proportion of reported new cases with multi-drug resistance (MDR) was 3.5%. METHODS: Contact tracing of a case of pulmonary tuberculosis was performed in a Bolivian patient. Diagnostic tests were performed according to national and local protocols. RESULTS: An outbreak of tuberculosis in an immigrant community was detected, with 5 cases originating from one index case. Genotyping and drug susceptibility testing of the sputum samples determined Mycobacterium tuberculosis resistant to isoniazid (KatG-msp unmutated/inhA 5RBS CT). Active case finding revealed a total of 39 contacts with an incidence of latent infection of 71.43%. CONCLUSIONS: The present study confirms the importance of active case finding through contact tracing as well as rapid laboratory diagnosis to achieve improvements in early detection of TB. Early diagnosis of the patient, compliance with appropriate treatment protocols and monitoring of drug resistance are considered essential for the prevention and control of TB.
Authors: V Rouzier; M Murrill; S Kim; L Naini; J Shenje; E Mitchell; M Raesi; M Lourens; A Mendoza; F Conradie; N Suryavanshi; M Hughes; S Shah; G Churchyard; S Swindells; A Hesseling; A Gupta Journal: Int J Tuberc Lung Dis Date: 2022-10-01 Impact factor: 3.427