Ferruh Artunc1, Günter Schnauder1, Baptist Gallwitz1, Bastian Amend2.
Abstract
HISTORY AND ADMISSION
FINDINGS: Two female patients aged over 80 years developed central nervous symptoms after drinking large amounts of water (more than 3 l per day). INVESTIGATIONS: Both had a hypoosmolar hyponatremia that was induced by concomitant treatment with hydrochlorothiazid (HCT) in the one case and in the other case relied on a distal tubular damage due to reflux nephropathy. DIAGNOSIS, TREATMENT AND COURSE: Hyponatremia was corrected after withdrawal of HCT and fluid restriction and central nervous symptoms disappeared rapidly.
CONCLUSIONS: Distal tubular urinary dilution can be disturbed by HCT and parenchymal renal disease and can result in symptomatic hyponatremia after drinking large amounts of water. © Georg Thieme Verlag KG Stuttgart · New York.
HISTORY AND ADMISSION
FINDINGS: Two female patients aged over 80 years developed central nervous symptoms after drinking large amounts of water (more than 3 l per day). INVESTIGATIONS: Both had a hypoosmolar hyponatremia that was induced by concomitant treatment with hydrochlorothiazid (HCT) in the one case and in the other case relied on a distal tubular damage due to reflux nephropathy. DIAGNOSIS, TREATMENT AND COURSE: Hyponatremia was corrected after withdrawal of HCT and fluid restriction and central nervous symptoms disappeared rapidly.
CONCLUSIONS: Distal tubular urinary dilution can be disturbed by HCT and parenchymal renal disease and can result in symptomatic hyponatremia after drinking large amounts of water. © Georg Thieme Verlag KG Stuttgart · New York.
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Year: 2015
PMID： 26583822 DOI： 10.1055/s-0041-105886
Source DB: PubMed Journal: Dtsch Med Wochenschr ISSN： 0012-0472 Impact factor: 0.628