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Literature DB >> 26582251

A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners.

Abstract

Small non-coding RNAs are indispensable to many biological processes. A class of endogenous small RNAs, termed PIWI-interacting RNAs (piRNAs) because of their association with PIWI proteins, has known roles in safeguarding the genome against inordinate transposon mobilization, embryonic development, and stem cell regulation, among others. This review discusses the biogenesis of animal piRNAs and their diverse functions together with their PIWI protein partners, both in the germline and in somatic cells, and highlights the evolutionarily conserved aspects of these molecular players in animal biology.

Entities: Gene

Keywords: Evolutionary conservation; Gene regulation; PIWI protein; PIWI-interacting RNA (piRNA); Transposable elements; piRNA biogenesis

Mesh：

Substances：

Year: 2015 PMID： 26582251 DOI： 10.1016/j.semcdb.2015.10.025

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

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Cited

19 in total

1. PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.

Authors: Imène Sarah Henaoui; Cécile Jacovetti; Inês Guerra Mollet; Claudiane Guay; Jonathan Sobel; Lena Eliasson; Romano Regazzi
Journal: Diabetologia Date: 2017-07-16 Impact factor: 10.122

2. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.

Authors: Ling Peng; Fengjuan Zhang; Renfu Shang; Xueyan Wang; Jiayi Chen; James J Chou; Jinbiao Ma; Ligang Wu; Ying Huang
Journal: J Biol Chem Date: 2018-04-27 Impact factor: 5.157

A piece of the pi(e): The diverse roles of animal piRNAs and their PIWI partners.

1. PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.

2. Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain.

3. Heterochromatic histone modifications at transposons in Xenopus tropicalis embryos.

Review 4. Protecting and Diversifying the Germline.

Review 5. Argonaute and Argonaute-Bound Small RNAs in Stem Cells.

Review 6. PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes.

7. Characterization of the piRNA pathway during development of the sea anemone Nematostella vectensis.

8. Increasing cell density globally enhances the biogenesis of Piwi-interacting RNAs in Bombyx mori germ cells.

9. Hunting for the ultimate liquid cancer biopsy - let the TEP dance begin.

Review 10. The Biogenesis and Functions of piRNAs in Human Diseases.