Literature DB >> 26582167

Presentation and outcome of patients treated non-operatively or operatively for Copenhagen Disease: a 30-year experience.

Francesc Malagelada1, Joseph S Butler2, Lylah Rajput2, Alexios Iliadis2, Reza Mansouri2, Asif Saifuddin3, Alexander Gibson2.   

Abstract

PURPOSE: Our purpose was to analyse the presentation, management and clinical outcome of patients treated operatively and non-operatively for Copenhagen Disease (CD).
METHODS: We performed a retrospective analysis of 10 patients (n = 10) with CD, with a mean follow-up time of 14.7 years. Seven patients underwent non-operative treatment and three patients were treated operatively. Clinical presentation and radiological findings were analysed. Health-related quality of life (HRQOL) outcome measures utilized included Oswestry Disability Index (ODI), Short Form 12 Health Survey (SF-12) and visual analogue scale (VAS).
RESULTS: Patients tended to present with back pain. No significant difference was detected in functional scores at time of diagnosis and when compared to last follow-up. ODI improved from 20.0 to 18.4 (p = 0.839), PCS component of SF-12 from 44.5 to 45.9 (p = 0.719), MCS component of SF-12 from 45.7 to 46.9 (p = 0.840) and VAS score remained at 2.8 (p = 1.000). There was no significant difference in functional scores when comparing operative and non-operative treatment groups.
CONCLUSION: CD is likely to remain stable with time or slightly improve after treatment according to functional outcomes tests. Progression of the kyphosis can be halted at different degrees with operative and non-operative treatments although it does not correlate with changes in symptomatology.

Entities:  

Keywords:  Copenhagen disease; Copenhagen syndrome; Kyphosis; Progressive anterior vertebral fusion; Radiology

Mesh:

Year:  2015        PMID: 26582167     DOI: 10.1007/s00586-015-4324-0

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  26 in total

Review 1.  The prevalence of low back pain: a systematic review of the literature from 1966 to 1998.

Authors:  B F Walker
Journal:  J Spinal Disord       Date:  2000-06

Review 2.  The intervertebral disk: a landmark for spinal diseases in children.

Authors:  Gabriel Kalifa; Pierre-Alain Cohen; Amine Hamidou
Journal:  Eur Radiol       Date:  2001-11-16       Impact factor: 5.315

3.  Progressive non-infectious anterior vertebral fusion ('Copenhagen disease').

Authors:  Dennis Stoker
Journal:  Clin Radiol       Date:  2002-01       Impact factor: 2.350

4.  Progressive non-infectious anterior vertebral fusion (Copenhagen Syndrome) in three children: features on radiographs and MR imaging.

Authors:  R J Hughes; A Saifuddin
Journal:  Skeletal Radiol       Date:  2005-11-18       Impact factor: 2.199

5.  Progressive vertebral fusion of unknown etiology: a case report.

Authors:  Jennifer H Farrior; David D Weaver; Thomas F Kling; Eugene Klatte
Journal:  Am J Med Genet       Date:  2002-10-01

6.  The limbus vertebra: an anterior disc herniation demonstrated by discography.

Authors:  B Ghelman; R H Freiberger
Journal:  AJR Am J Roentgenol       Date:  1976-11       Impact factor: 3.959

7.  Progressive noninfectious anterior vertebral fusion: MRI findings and association with a lipoma of the filum terminale in a 5-year-old girl.

Authors:  J C Décarie; P S Babyn
Journal:  Pediatr Radiol       Date:  1993

8.  Long-term clinical and radiological outcomes of Copenhagen syndrome with 19 affected levels: a case report.

Authors:  Francesc Malagelada; Mathew D Sewell; Amr Fahmy; Alexander Gibson
Journal:  Spine J       Date:  2014-12-06       Impact factor: 4.166

9.  Congenital kyphosis by segmentation defect: etiologic and pathogenic studies.

Authors:  B Morin; B Poitras; M Duhaime; C H Rivard; D Marton
Journal:  J Pediatr Orthop       Date:  1985 May-Jun       Impact factor: 2.324

10.  [Progressive anterior vertebral fusion in children (author's transl)].

Authors:  K Kharrat; J Dubousset
Journal:  Rev Chir Orthop Reparatrice Appar Mot       Date:  1980 Nov-Dec
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