Literature DB >> 26580241

Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor.

Anne Laure Coulon1, Frédérique Savagner1, Claire Briet1, Marie Vernin1, Mathilde Munier1, Olivier Chabre1, Patrice Rodien1.   

Abstract

CONTEXT: Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion. CASE DESCRIPTION: We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG.
CONCLUSION: Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.

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Year:  2015        PMID： 26580241     DOI： 10.1210/jc.2015-3670

Source DB:  PubMed          Journal:  J Clin Endocrinol Metab        ISSN： 0021-972X            Impact factor:   5.958


  7 in total

1.  Variables Contributing to Thyroid (Dys)Function in Pregnant Women: More than Thyroid Antibodies?

Authors:  Flora Veltri; Kris Poppe
Journal:  Eur Thyroid J       Date:  2018-04-27

Review 2.  Nausea and vomiting of pregnancy - What's new?

Authors:  Martha Bustos; Raman Venkataramanan; Steve Caritis
Journal:  Auton Neurosci       Date:  2016-05-13       Impact factor: 3.145

3.  A CASE OF FAMILIAL NONAUTOIMMUNE HYPERTHYROIDISM DURING PREGNANCY.

Authors:  Yuka Okazaki; Naoko Arata; Nagayoshi Umehara; Taisuke Yamauchi; Junnichi Tajiri; Akira Hishinuma; Takahiko Kogai; Takashi Idegami; Atsuko Murashima; Haruhiko Sago
Journal:  AACE Clin Case Rep       Date:  2020-01-22

4.  Severe thyrotoxicosis in an infant revealing familial nonautoimmune hyperthyroidism with a novel (C672W) stimulating thyrotropin receptor germline mutation.

Authors:  Isabelle Oliver-Petit; Frédérique Savagner; Solange Grunenwald; Magaly Vialon; Thomas Edouard; Philippe Caron
Journal:  Clin Case Rep       Date:  2017-10-25

Review 5.  Benign thyroid disease in pregnancy: A state of the art review.

Authors:  Efterpi Tingi; Akheel A Syed; Alexis Kyriacou; George Mastorakos; Angelos Kyriacou
Journal:  J Clin Transl Endocrinol       Date:  2016-11-23

6.  Genetic analysis of hyperemesis gravidarum reveals association with intracellular calcium release channel (RYR2).

Authors:  Marlena Schoenberg Fejzo; Ronny Myhre; Lucía Colodro-Conde; Kimber W MacGibbon; Janet S Sinsheimer; M V Prasad Linga Reddy; Päivi Pajukanta; Dale R Nyholt; Margaret J Wright; Nicholas G Martin; Stephanie M Engel; Sarah E Medland; Per Magnus; Patrick M Mullin
Journal:  Mol Cell Endocrinol       Date:  2016-09-20       Impact factor: 4.369

7.  Associations of vomiting and antiemetic use in pregnancy with levels of circulating GDF15 early in the second trimester: A nested case-control study.

Authors:  Clive J Petry; Ken K Ong; Keith A Burling; Peter Barker; Sandra F Goodburn; John R B Perry; Carlo L Acerini; Ieuan A Hughes; Rebecca C Painter; Gijs B Afink; David B Dunger; Stephen O'Rahilly
Journal:  Wellcome Open Res       Date:  2018-09-21
  7 in total

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