Literature DB >> 26576625

Fabrication and characterization of cefazolin-loaded nanofibrous mats for the recovery of post-surgical wound.

Goutam Rath1,2, Taqadus Hussain1, Gaurav Chauhan1, Tarun Garg1, Amit Kumar Goyal1.   

Abstract

The aim of the present study was to evaluate the wound healing performance of cefazolin-loaded gelatin nanofiber mats in post-operative wound. The obtained nanofibers were smooth, non-beaded and having diameter ranging from 620-680 nm. Nanofiber mats that are prepared exhibit high drug entrapment, excellent oxygen permeability and sustained drug release behavior. Further, medicated nanofiber mats showed an accelerated wound healing as compared to plain cefazolin. Macroscopical and histological evaluations demonstrated that cefazolin-loaded gelatin nanofiber showed increased epithelialization rate and collagen deposition. The results indicated that therapeutic strategies offer new prospects in the management of post-operative wound repair.

Entities:  

Keywords:  Cefazolin; controlled drug release; gelatin nanofibers; post-operative wound healing

Mesh：

Substances：

Year:  2015        PMID： 26576625     DOI： 10.3109/21691401.2015.1102741

Source DB:  PubMed          Journal:  Artif Cells Nanomed Biotechnol        ISSN： 2169-1401            Impact factor:   5.678


  4 in total

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Review 3.  Nanochemistry of Protein-Based Delivery Agents.

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Journal:  Front Chem       Date:  2016-07-20       Impact factor: 5.221

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  4 in total

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