| Literature DB >> 26575974 |
Jie Sun1,2, Michel Sadelain1,2.
Abstract
Chimeric antigen receptors (CARs) are synthetic receptors capable of directing potent antigen-specific anti-tumor T cell responses. A recent report by Wu et al. extends a series of strategies aiming to curb excessive T cell activity, utilizing in this instance a chemical dimerizer to aggregate antigen-binding, T cell-activating and costimulatory domains.Entities:
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Year: 2015 PMID： 26575974 PMCID： PMC4670991 DOI： 10.1038/cr.2015.131
Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617