PURPOSE OF REVIEW: Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease. RECENT FINDINGS: Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens. SUMMARY: Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.
PURPOSE OF REVIEW: Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease. RECENT FINDINGS: Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens. SUMMARY: Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.
Authors: Keisa W Mathis; Kedra Wallace; Elizabeth R Flynn; Christine Maric-Bilkan; Babbette LaMarca; Michael J Ryan Journal: Hypertension Date: 2014-07-14 Impact factor: 10.190
Authors: Heddwen L Brooks; Meredith Hay; Dennis P Pollow; Jennifer Uhrlaub; Melissa Romero-Aleshire; Kathryn Sandberg; Janko Nikolich-Zugich Journal: Hypertension Date: 2014-06-02 Impact factor: 10.190
Authors: Bradley T Endres; Ruben M Sandoval; George J Rhodes; Silvia B Campos-Bilderback; Malgorzata M Kamocka; Christopher McDermott-Roe; Alexander Staruschenko; Bruce A Molitoris; Aron M Geurts; Oleg Palygin Journal: Am J Physiol Renal Physiol Date: 2017-04-12
Authors: Ammar J Alsheikh; Hayley Lund; John Henry Dasinger; Justine M Abais-Battad; Daniel J Fehrenbach; David L Mattson Journal: Am J Physiol Regul Integr Comp Physiol Date: 2019-06-05 Impact factor: 3.619