Literature DB >> 26575161

Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis.

Heeseon An1, Alexander V Statsyuk.   

Abstract

We report a facile synthetic strategy to prepare UBL-AMP electrophilic probes that form a covalent bond with the catalytic cysteine of cognate E1s, mimicking the tetrahedral intermediate of the E1-UBL-AMP complex. These probes enable the structural and biochemical study of both canonical- and non-canonical E1s.

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Year:  2015        PMID： 26575161     DOI： 10.1039/c5cc08592f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  Decoding the messaging of the ubiquitin system using chemical and protein probes.

Authors:  Lukas T Henneberg; Brenda A Schulman
Journal:  Cell Chem Biol       Date:  2021-04-07       Impact factor: 8.116

2.  Site-Specific Conversion of Cysteine in a Protein to Dehydroalanine Using 2-Nitro-5-thiocyanatobenzoic Acid.

Authors:  Yuchen Qiao; Ge Yu; Sunshine Z Leeuwon; Wenshe Ray Liu
Journal:  Molecules       Date:  2021-04-29       Impact factor: 4.411

Review 3.  Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism.

Authors:  Laurent Cappadocia; Christopher D Lima
Journal:  Chem Rev       Date:  2017-02-24       Impact factor: 60.622

Review 4.  Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

Authors:  David S Hewings; John A Flygare; Matthew Bogyo; Ingrid E Wertz
Journal:  FEBS J       Date:  2017-03-10       Impact factor: 5.542

Review 5.  How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling.

Authors:  Gerbrand J van der Heden van Noort; Huib Ovaa
Journal:  Curr Top Microbiol Immunol       Date:  2019       Impact factor: 4.291

6.  A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Authors:  Monique P C Mulder; Katharina Witting; Ilana Berlin; Jonathan N Pruneda; Kuen-Phon Wu; Jer-Gung Chang; Remco Merkx; Johanna Bialas; Marcus Groettrup; Alfred C O Vertegaal; Brenda A Schulman; David Komander; Jacques Neefjes; Farid El Oualid; Huib Ovaa
Journal:  Nat Chem Biol       Date:  2016-05-16       Impact factor: 15.040

Review 7.  Synthetic and semi-synthetic strategies to study ubiquitin signaling.

Authors:  Gabriëlle Ba van Tilburg; Angela F Elhebieshy; Huib Ovaa
Journal:  Curr Opin Struct Biol       Date:  2016-06-15       Impact factor: 6.809

Review 8.  Tools for Decoding Ubiquitin Signaling in DNA Repair.

Authors:  Benjamin Foster; Martin Attwood; Ian Gibbs-Seymour
Journal:  Front Cell Dev Biol       Date:  2021-12-07
  8 in total

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