BACKGROUND: Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker in blood. OBJECTIVE: This study was undertaken to examine candidate microRNAs in plasma to determine whether changes observed in HD brains are detectable in peripheral samples. METHODS: Four microRNAs from 26 manifest Huntington's disease, four asymptomatic Huntington's disease gene carriers, and eight controls were quantified in plasma using reverse transcription quantitative polymerase chain reaction. Linear regression was used to assess microRNA levels across control, asymptomatic gene carriers, and manifest patients. RESULTS: miR-10b-5p (P = 0.0068) and miR-486-5p (P = 0.044) were elevated in Huntington's disease plasma. miR-10b-5p was decreased in asymptomatic gene carriers as compared with patients with Huntington's disease (P = 0.049), but no difference between asymptomatic gene carriers and healthy controls was observed (P = 0.24). CONCLUSIONS: These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility.
BACKGROUND: Biomarkers for Huntington's disease progression could accelerate therapeutic developments and improve patient care. Brain microRNAs relating to clinical features of Huntington's disease may represent a potential Huntington's disease biomarker in blood. OBJECTIVE: This study was undertaken to examine candidate microRNAs in plasma to determine whether changes observed in HD brains are detectable in peripheral samples. METHODS: Four microRNAs from 26 manifest Huntington's disease, four asymptomatic Huntington's disease gene carriers, and eight controls were quantified in plasma using reverse transcription quantitative polymerase chain reaction. Linear regression was used to assess microRNA levels across control, asymptomatic gene carriers, and manifest patients. RESULTS:miR-10b-5p (P = 0.0068) and miR-486-5p (P = 0.044) were elevated in Huntington's disease plasma. miR-10b-5p was decreased in asymptomatic gene carriers as compared with patients with Huntington's disease (P = 0.049), but no difference between asymptomatic gene carriers and healthy controls was observed (P = 0.24). CONCLUSIONS: These findings suggest that microRNA changes observed in Huntington's disease brain may be detectable in plasma and have potential clinical utility.
Authors: Laura Poliseno; Min Sup Song; Su Jung Song; Ugo Ala; Kaitlyn Webster; Christopher Ng; Gary Beringer; Nicolai J Brikbak; Xin Yuan; Lewis C Cantley; Andrea L Richardson; Pier Paolo Pandolfi Journal: Cell Date: 2013-07-03 Impact factor: 41.582
Authors: Jane S Paulsen; Jeffrey D Long; Christopher A Ross; Deborah L Harrington; Cheryl J Erwin; Janet K Williams; Holly James Westervelt; Hans J Johnson; Elizabeth H Aylward; Ying Zhang; H Jeremy Bockholt; Roger A Barker Journal: Lancet Neurol Date: 2014-11-03 Impact factor: 44.182
Authors: F Borovecki; L Lovrecic; J Zhou; H Jeong; F Then; H D Rosas; S M Hersch; P Hogarth; B Bouzou; R V Jensen; D Krainc Journal: Proc Natl Acad Sci U S A Date: 2005-07-25 Impact factor: 11.205
Authors: Rawaha Ahmad; Sophie Bourgeois; Andrey Postnov; Mark E Schmidt; Guy Bormans; Koen Van Laere; Wim Vandenberghe Journal: Neurology Date: 2013-12-18 Impact factor: 9.910
Authors: Aaron Sturrock; Corree Laule; Katy Wyper; Ruth A Milner; Joji Decolongon; Rachelle Dar Santos; Allison J Coleman; Kimberley Carter; Susan Creighton; Natalie Bechtel; Stefan Bohlen; Ralf Reilmann; Hans J Johnson; Michael R Hayden; Sarah J Tabrizi; Alex L Mackay; Blair R Leavitt Journal: Mov Disord Date: 2015-02-18 Impact factor: 10.338
Authors: Deborah L Harrington; Dawei Liu; Megan M Smith; James A Mills; Jeffrey D Long; Elizabeth H Aylward; Jane S Paulsen Journal: Brain Behav Date: 2013-11-13 Impact factor: 2.708
Authors: Andrew G Hoss; Adam Labadorf; Jeanne C Latourelle; Vinay K Kartha; Tiffany C Hadzi; James F Gusella; Marcy E MacDonald; Jiang-Fan Chen; Schahram Akbarian; Zhiping Weng; Jean Paul Vonsattel; Richard H Myers Journal: BMC Med Genomics Date: 2015-03-01 Impact factor: 3.063
Authors: Beth Borowsky; John Warner; Blair R Leavitt; Sarah J Tabrizi; Raymund A C Roos; Alexandra Durr; Chris Becker; Cristina Sampaio; Allan J Tobin; Howard Schulman Journal: Neurology Date: 2013-04-24 Impact factor: 9.910
Authors: Heather H Cheng; Hye Son Yi; Yeonju Kim; Evan M Kroh; Jason W Chien; Keith D Eaton; Marc T Goodman; Jonathan F Tait; Muneesh Tewari; Colin C Pritchard Journal: PLoS One Date: 2013-06-07 Impact factor: 3.240
Authors: Andrew G Hoss; Vinay K Kartha; Xianjun Dong; Jeanne C Latourelle; Alexandra Dumitriu; Tiffany C Hadzi; Marcy E Macdonald; James F Gusella; Schahram Akbarian; Jiang-Fan Chen; Zhiping Weng; Richard H Myers Journal: PLoS Genet Date: 2014-02-27 Impact factor: 5.917
Authors: Eric R Reed; Jeanne C Latourelle; Jeremy H Bockholt; Joli Bregu; Justin Smock; Jane S Paulsen; Richard H Myers Journal: Neurology Date: 2017-12-27 Impact factor: 11.800