Literature DB >> 26572990

The LAST guidelines in clinical practice: implementing recommendations for p16 use.

Lani K Clinton1, Kyle Miyazaki2, Asia Ayabe2, James Davis3, Pamela Tauchi-Nishi4, David Shimizu4.   

Abstract

OBJECTIVES: To determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared p16 use and follow-up data before and after implementation of the guidelines.
METHODS: We reviewed all cervical biopsy specimens diagnosed by two pathologists before and after implementation of the LAST guidelines and calculated the rate of and reason for p16 use across all biopsy specimens, high-grade squamous intraepithelial lesion (HSIL) detection, and follow-up.
RESULTS: In total, 1,829 and 1,623 cervical biopsy specimens were reviewed in periods A and B, respectively. Overall p16 use increased from 2.8% to 6.2% (P < .001). Recommendations 2 and 4 increased from 0.16% and 0% of all cervical biopsy specimens in period A to 1.4% and 1.9% in period B, respectively (P < .0001). p16+ HSIL increased from 1.4% to 2.3% (P < .05). The positive predictive value of p16+ HSIL increased from 48% to 76% (P < .05).
CONCLUSIONS: Implementation of the p16 LAST guidelines resulted in a significant increase in p16 use and a significant increase in the positive predictive value of p16+ HSIL. Copyright© by the American Society for Clinical Pathology.

Entities:  

Keywords:  Cervical pathology; Gynecologic pathology; LAST guidelines; p16

Mesh：

Substances：

Year:  2015        PMID： 26572990     DOI： 10.1309/AJCPUXLP7XD8OQYY

Source DB:  PubMed          Journal:  Am J Clin Pathol        ISSN： 0002-9173            Impact factor:   2.493


  11 in total

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Review 3.  Current and Emerging Molecular Tests for Human Papillomavirus-Related Neoplasia in the Genomic Era.

Authors:  Sixto M Leal; Margaret L Gulley
Journal:  J Mol Diagn       Date:  2017-03-18       Impact factor: 5.568

4.  Diagnostic Usefulness of p16 Immunohistochemistry for some Epithelial Lesions in the Pathology Service of Sultan Qaboos University Hospital.

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Journal:  Maedica (Bucur)       Date:  2021-12

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Journal:  NPJ Precis Oncol       Date:  2022-06-29

6.  The value of p16INK4a immunostaining for high-grade squamous intraepithelial lesions in human papillomavirus-negative patients.

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Journal:  BMC Womens Health       Date:  2022-04-27       Impact factor: 2.742

7.  Classifying Anal Intraepithelial Neoplasia 2 Based on LAST Recommendations.

Authors:  Yuxin Liu; W Glenn McCluggage; Teresa M Darragh; Wenxin Zheng; Jennifer M Roberts; Kay J Park; Pei Hui; Morgan Blakely; Keith Sigel; Michael M Gaisa
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Journal:  J Pathol Clin Res       Date:  2018-09-21

9.  P16 as a marker of carcinoma in effusions and peritoneal washing.

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