Literature DB >> 2657245

Cimetidine as an immune response modifier.

R Hast1, P Bernell, M Hansson.   

Abstract

Cimetidine, a selective histamine-2 receptor antagonist, has attracted interest because of its potential as an immune response-modifying drug. Most data suggest that cimetidine has a stimulatory action on the immune system, possibly by blocking of receptors on subsets of T-lymphocytes and inhibiting histamine-induced immune suppression. Several studies have shown that cimetidine can affect the relative number of CD8 + ve lymphocytes and increase the NK cell activity as well as the antibody-dependent cellular cytotoxicity. Cimetidine has also been used successfully to restore immune functions in patients with malignant disorders, hypogammaglobulinemia and AIDS-related complexes.

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Year:  1989        PMID： 2657245     DOI： 10.1007/bf02985231

Source DB:  PubMed          Journal:  Med Oncol Tumor Pharmacother        ISSN： 0736-0118


  23 in total

1.  Histamine suppression of human lymphocyte responses to mitogens.

Authors:  S R Wang; B Zweiman
Journal:  Cell Immunol       Date:  1978-03-01       Impact factor: 4.868

2.  Immunomodulatory properties of cimetidine in ARC patients.

Authors:  N H Brockmeyer; E Kreuzfelder; L Mertins; N Chalabi; W Kirch; N Scheiermann; M Goos; E E Ohnhaus
Journal:  Clin Immunol Immunopathol       Date:  1988-07

3.  Postburn immunosuppression in an animal model. III. Maintenance of normal splenic helper and suppressor lymphocyte subpopulations by immunomodulating drugs.

Authors:  R L Zapata-Sirvent; J F Hansbrough
Journal:  Surgery       Date:  1985-06       Impact factor: 3.982

4.  Modulation of suppressor-cell activity by cimetidine in patients with common variable hypogammaglobulinemia.

Authors:  W B White; M Ballow
Journal:  N Engl J Med       Date:  1985-01-24       Impact factor: 91.245

Review 5.  Histamine-induced suppressor-cell activity.

Authors:  D J Beer; R E Rocklin
Journal:  J Allergy Clin Immunol       Date:  1984-04       Impact factor: 10.793

6.  The immune restorative effect of cimetidine administration in vivo on the local graft-versus-host reaction of cancer patients.

Authors:  M Talpaz; J E Medina; Y Z Patt; H Goepfert; O M Guillamondegui; W Wong; G M Mavligit
Journal:  Clin Immunol Immunopathol       Date:  1982-08

7.  Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine.

Authors:  J Ankerst; R Fäldt; P G Nilsson; P Flodgren; H O Sjögren
Journal:  Cancer Immunol Immunother       Date:  1984       Impact factor: 6.968

8.  Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon.

Authors:  P Flodgren; H O Sjögren
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

9.  Effect of histamine and histamine antagonists on natural and antibody-dependent cellular cytotoxicity of human lymphocytes in vitro.

Authors:  M P Nair; S A Schwartz
Journal:  Cell Immunol       Date:  1983-10-01       Impact factor: 4.868

10.  Cimetidine-associated exacerbation of cutaneous lupus erythematosus.

Authors:  B L Davidson; J N Gilliam; P E Lipsky
Journal:  Arch Intern Med       Date:  1982-01
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  1 in total

1.  Protective Effects of IMOD and Cimetidine against Radiation-induced Cellular Damage.

Authors:  S Rahgoshai; M Mohammadi; S Refahi; M Oladghaffari; S M R Aghamiri
Journal:  J Biomed Phys Eng       Date:  2018-03-01
  1 in total

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