Todd R Sponholtz1, Dale P Sandler2, Christine G Parks2, Katie M Applebaum3,4. 1. Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts. 2. Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina. 3. Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, District of Columbia. 4. Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
Abstract
BACKGROUND: Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case-control study. METHODS: Newly diagnosed cases of CKD (n = 547) and controls (n = 508) from North Carolina provided detailed work histories in telephone interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: There was heterogeneity in the association of CKD and agricultural work, with crop production associated with increased risk and work with livestock associated with decreased risk. Work with cutting/cooling/lubricating oils was associated with a reduced risk. CKD risk was increased for working in dusty conditions. CONCLUSIONS: CKD risk was reduced in subjects with occupational exposures previously reported to involve endotoxin exposure. Further, exposure to dusty conditions was consistently associated with increased risk of glomerulonephritis across industry, suggesting that research on CKD and ultrafine particulates is needed.
BACKGROUND:Chronic kidney disease (CKD) carries a high public health burden yet there is limited research on occupational factors, which are examined in this retrospective case-control study. METHODS: Newly diagnosed cases of CKD (n = 547) and controls (n = 508) from North Carolina provided detailed work histories in telephone interviews. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: There was heterogeneity in the association of CKD and agricultural work, with crop production associated with increased risk and work with livestock associated with decreased risk. Work with cutting/cooling/lubricating oils was associated with a reduced risk. CKD risk was increased for working in dusty conditions. CONCLUSIONS: CKD risk was reduced in subjects with occupational exposures previously reported to involve endotoxin exposure. Further, exposure to dusty conditions was consistently associated with increased risk of glomerulonephritis across industry, suggesting that research on CKD and ultrafine particulates is needed.
Authors: J A Staessen; R R Lauwerys; J P Buchet; C J Bulpitt; D Rondia; Y Vanrenterghem; A Amery Journal: N Engl J Med Date: 1992-07-16 Impact factor: 91.245
Authors: G Gregorini; A Ferioli; F Donato; P Tira; L Morassi; R Tardanico; L Lancini; R Maiorca Journal: Adv Exp Med Biol Date: 1993 Impact factor: 2.622
Authors: G D Nuyts; E Van Vlem; J Thys; D De Leersnijder; P C D'Haese; M M Elseviers; M E De Broe Journal: Lancet Date: 1995-07-01 Impact factor: 79.321
Authors: D P Sandler; J C Smith; C R Weinberg; V M Buckalew; V W Dennis; W B Blythe; W P Burgess Journal: N Engl J Med Date: 1989-05-11 Impact factor: 91.245
Authors: Carmine Zoccali; Raymond Vanholder; Ziad A Massy; Alberto Ortiz; Pantelis Sarafidis; Friedo W Dekker; Danilo Fliser; Denis Fouque; Gunnar H Heine; Kitty J Jager; Mehmet Kanbay; Francesca Mallamaci; Gianfranco Parati; Patrick Rossignol; Andrzej Wiecek; Gerard London Journal: Nat Rev Nephrol Date: 2017-04-24 Impact factor: 28.314
Authors: Srishti Shrestha; Christine G Parks; Alexander P Keil; David M Umbach; Catherine C Lerro; Charles F Lynch; Honglei Chen; Aaron Blair; Stella Koutros; Jonathan N Hofmann; Laura E Beane Freeman; Dale P Sandler Journal: Occup Environ Med Date: 2019-09 Impact factor: 4.402
Authors: Deepika Shrestha; Sally Picciotto; Michael P LaValley; Sa Liu; S Katharine Hammond; Daniel E Weiner; Ellen A Eisen; Katie M Applebaum Journal: Occup Environ Med Date: 2021-07-01 Impact factor: 4.948