| Literature DB >> 26571192 |
Yangyang Zhai1,2, Xiangshuai Zhao1,2, Zhengjie Cui1,2, Man Wang1,2, Yaxin Wang3, Linfeng Li1,2, Qi Sun4, Xi Yang1,2, Debin Zeng1,2, Ying Liu1,2, Yuna Sun5, Zhiyong Lou3, Luqing Shang1,2, Zheng Yin1,2.
Abstract
Cyanohydrin derivatives as enterovirus 71 (EV71) 3C protease (3C(pro)) inhibitors have been synthesized and assayed for their biochemical and antiviral activities. Compared with the reported inhibitors, cyanohydrins (1S,2S,2'S,5S)-16 and (1R,2S,2'S,5S)-16 exhibited significantly improved activity and attractive selectivity profiles against other proteases, which were a result of the specific interactions between the cyanohydrin moiety and the catalytic site of 3C(pro). Cyanohydrin as an anchoring group with high selectivity and excellent inhibitory activity represents a useful choice for cysteine protease inhibitors.Entities:
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Year: 2015 PMID： 26571192 DOI： 10.1021/acs.jmedchem.5b01013
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446