| Literature DB >> 26570985 |
Maobin Xie1, Dejun Fan2, Zheng Zhao3, Zhi Li4, Gang Li5, Yufeng Chen2, Xiaowen He2, Aizheng Chen6, Jiashen Li1, Xiaofen Lin1, Min Zhi2, Yi Li7, Ping Lan8.
Abstract
Curcumin (CM) possesses multiple biological activities. However, poor water solubility and low bioavailability limit its application in biomedical fields. CM nanoparticles (NPs) (230-240nm) were prepared by solution-enhanced dispersion via supercritical CO2 (SEDS) (22-22.5MPa pressure, 31-32.5°C temperature) and its biological functions were evaluated in this study. The Minimum inhibitory concentration of CM NPs against S. aureus (∼250μg/mL) was lower than CM-DMSO (∼500μg/mL). Meanwhile, CM NPs showed effective anti-oxidant ability at a concentration raging from 125 to 2000μg/mL. CM NPs showed time-dependent intracellular internalization ability, resulting in an enhanced anti-cancer effect on colorectal cancer cells (HCT116), and the mechanism could be explained by cell cycle arrest in G2/M phase associated with inducing apoptotic cells. Moreover, CM NPs exhibited reduced cytotoxicity on normal cells (NCM460) compared to CM-DMSO and 5-Fu. In conclusion, CM NPs prepared via SEDS showed potentials in biomedical applications.Entities:
Keywords: Anti-bacterial; Anti-cancer; Anti-oxidant; Curcumin; Supercritical CO(2)
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Year: 2015 PMID： 26570985 DOI： 10.1016/j.ijpharm.2015.11.016
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875