Thomas J Giordano1. 1. aDepartment of Pathology bDepartment of Internal Medicine cUniversity of Michigan Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, Michigan, USA.
Abstract
PURPOSE OF REVIEW: The present review is focused on the recently published study on the genomics of papillary thyroid carcinoma performed by The Cancer Genome Atlas Research Network and its implications for the follicular variant of papillary carcinoma. RECENT FINDINGS: The Cancer Genome Atlas study of papillary thyroid carcinoma comprehensively examined the cancer genome of nearly 500 primary tumors. Using a highly integrated bioinformatic analysis, papillary carcinoma was shown at the genomic level to consist of two highly distinct classes that reflected both tumor histology and underlying genotype. Tumors with true papillary architecture were dominated by BRAF(V600E) mutations and RET kinase fusions and were designated as BRAF(V600E)-like. Tumors with follicular architecture were conversely dominated by RAS mutations and were designated as RAS-like. Given the strong genotype:phenotype correlation known to be present in thyroid cancer, the separation of BRAF(V600E)-like and RAS-like tumors has profound implications for its classification, especially the follicular variant of papillary carcinoma. SUMMARY: The recent genomic characterization of papillary thyroid carcinoma is challenging the established pathological classification of thyroid cancer with significance for the care of patients.
PURPOSE OF REVIEW: The present review is focused on the recently published study on the genomics of papillary thyroid carcinoma performed by The Cancer Genome Atlas Research Network and its implications for the follicular variant of papillary carcinoma. RECENT FINDINGS: The Cancer Genome Atlas study of papillary thyroid carcinoma comprehensively examined the cancer genome of nearly 500 primary tumors. Using a highly integrated bioinformatic analysis, papillary carcinoma was shown at the genomic level to consist of two highly distinct classes that reflected both tumor histology and underlying genotype. Tumors with true papillary architecture were dominated by BRAF(V600E) mutations and RET kinase fusions and were designated as BRAF(V600E)-like. Tumors with follicular architecture were conversely dominated by RAS mutations and were designated as RAS-like. Given the strong genotype:phenotype correlation known to be present in thyroid cancer, the separation of BRAF(V600E)-like and RAS-liketumors has profound implications for its classification, especially the follicular variant of papillary carcinoma. SUMMARY: The recent genomic characterization of papillary thyroid carcinoma is challenging the established pathological classification of thyroid cancer with significance for the care of patients.
Authors: Jarosław Jendrzejewski; Sandya Liyanarachchi; Andrew Eiterman; Andrew Thomas; Huiling He; Rebecca Nagy; Leigha Senter; Krzysztof Sworczak; Albert de la Chapelle Journal: Int J Cancer Date: 2018-12-03 Impact factor: 7.396
Authors: Vera Tiedje; Saskia Ting; Thomas Herold; Sarah Synoracki; Soeren Latteyer; Lars C Moeller; Denise Zwanziger; Martin Stuschke; Dagmar Fuehrer; Kurt Werner Schmid Journal: Oncotarget Date: 2017-06-27