Literature DB >> 26568623

MIEC-SVM: automated pipeline for protein peptide/ligand interaction prediction.

Nan Li1, Richard I Ainsworth1, Meixin Wu1, Bo Ding1, Wei Wang1.   

Abstract

MOTIVATION: MIEC-SVM is a structure-based method for predicting protein recognition specificity. Here, we present an automated MIEC-SVM pipeline providing an integrated and user-friendly workflow for construction and application of the MIEC-SVM models. This pipeline can handle standard amino acids and those with post-translational modifications (PTMs) or small molecules. Moreover, multi-threading and support to Sun Grid Engine (SGE) are implemented to significantly boost the computational efficiency.
AVAILABILITY AND IMPLEMENTATION: The program is available at http://wanglab.ucsd.edu/MIEC-SVM CONTACT: : wei-wang@ucsd.edu SUPPLEMENTARY INFORMATION: Supplementary data available at Bioinformatics online.
© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

Mesh:

Substances:

Year:  2015        PMID: 26568623      PMCID: PMC4907390          DOI: 10.1093/bioinformatics/btv666

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  10 in total

1.  Characterization of domain-peptide interaction interface: a case study on the amphiphysin-1 SH3 domain.

Authors:  Tingjun Hou; Wei Zhang; David A Case; Wei Wang
Journal:  J Mol Biol       Date:  2008-01-03       Impact factor: 5.469

2.  Characterization of domain-peptide interaction interface: a generic structure-based model to decipher the binding specificity of SH3 domains.

Authors:  Tingjun Hou; Zheng Xu; Wei Zhang; William A McLaughlin; David A Case; Yang Xu; Wei Wang
Journal:  Mol Cell Proteomics       Date:  2008-11-20       Impact factor: 5.911

3.  Characterizing binding of small molecules. II. Evaluating the potency of small molecules to combat resistance based on docking structures.

Authors:  Bo Ding; Nan Li; Wei Wang
Journal:  J Chem Inf Model       Date:  2013-04-30       Impact factor: 4.956

4.  Characterization of PDZ domain-peptide interaction interface based on energetic patterns.

Authors:  Nan Li; Tingjun Hou; Bo Ding; Wei Wang
Journal:  Proteins       Date:  2011-09-17

5.  Characterization of domain-peptide interaction interface: prediction of SH3 domain-mediated protein-protein interaction network in yeast by generic structure-based models.

Authors:  Tingjun Hou; Nan Li; Youyong Li; Wei Wang
Journal:  J Proteome Res       Date:  2012-04-09       Impact factor: 4.466

6.  Characterization of small molecule binding. I. Accurate identification of strong inhibitors in virtual screening.

Authors:  Bo Ding; Jian Wang; Nan Li; Wei Wang
Journal:  J Chem Inf Model       Date:  2013-01-09       Impact factor: 4.956

7.  Improved prediction of protein side-chain conformations with SCWRL4.

Authors:  Georgii G Krivov; Maxim V Shapovalov; Roland L Dunbrack
Journal:  Proteins       Date:  2009-12

8.  Predicting drug resistance of the HIV-1 protease using molecular interaction energy components.

Authors:  Tingjun Hou; Wei Zhang; Jian Wang; Wei Wang
Journal:  Proteins       Date:  2009-03

9.  Predicting PDZ domain-peptide interactions from primary sequences.

Authors:  Jiunn R Chen; Bryan H Chang; John E Allen; Michael A Stiffler; Gavin MacBeath
Journal:  Nat Biotechnol       Date:  2008-09       Impact factor: 54.908

10.  Predicting PDZ domain mediated protein interactions from structure.

Authors:  Shirley Hui; Xiang Xing; Gary D Bader
Journal:  BMC Bioinformatics       Date:  2013-01-21       Impact factor: 3.169

  10 in total
  3 in total

1.  Sparse support vector machines with L0 approximation for ultra-high dimensional omics data.

Authors:  Zhenqiu Liu; David Elashoff; Steven Piantadosi
Journal:  Artif Intell Med       Date:  2019-04-30       Impact factor: 5.326

Review 2.  Prediction of Protein-Protein Interactions by Evidence Combining Methods.

Authors:  Ji-Wei Chang; Yan-Qing Zhou; Muhammad Tahir Ul Qamar; Ling-Ling Chen; Yu-Duan Ding
Journal:  Int J Mol Sci       Date:  2016-11-22       Impact factor: 5.923

3.  Deciphering and engineering chromodomain-methyllysine peptide recognition.

Authors:  Ryan Hard; Nan Li; Wei He; Brian Ross; Gary C H Mo; Qin Peng; Richard S L Stein; Elizabeth Komives; Yingxiao Wang; Jin Zhang; Wei Wang
Journal:  Sci Adv       Date:  2018-11-07       Impact factor: 14.136

  3 in total

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