Literature DB >> 26568551

Chemotherapy for Nasopharyngeal Carcinoma - Current Recommendation and Controversies.

Henry Sze1, Pierre Blanchard2, Wai Tong Ng3, Jean-Pierre Pignon4, Anne W M Lee1.   

Abstract

Radiotherapy is the primary treatment of nasopharyngeal carcinoma and combination chemotherapy can enhance treatment outcomes for locoregionally advanced disease. The Intergroup 0099 study using concurrent-adjuvant cisplatin-based chemoradiotherapy was the first trial to demonstrate a survival benefit. Since then, there have been attempts to further improve the treatment results by altering the chemotherapy sequence, using different chemotherapeutic agents or schedules, and extending the use of chemotherapy to early-stage disease. This review provides an overview of the data and highlights the current controversies behind international guidelines.
Copyright © 2015 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Chemoradiotherapy; Meta-analysis; Nasopharyngeal carcinoma; Randomized trial; Therapeutic benefit

Mesh：

Year:  2015        PMID： 26568551     DOI： 10.1016/j.hoc.2015.07.004

Source DB:  PubMed          Journal:  Hematol Oncol Clin North Am        ISSN： 0889-8588            Impact factor:   3.722


  14 in total

1.  IMB-6G induces endoplasmic reticulum stress-mediated apoptosis in human nasopharyngeal carcinoma cells.

Authors:  Yeting Pan; Yanni Zhang; Liang Gong; Jianding Zou; Boxia Hu; Sicong Zhang
Journal:  Exp Ther Med       Date:  2018-09-11       Impact factor: 2.447

2.  Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.

Authors:  I-Che Chung; Lih-Chyang Chen; Ngan-Ming Tsang; Wen-Yu Chuang; Tzu-Chieh Liao; Sheng-Ning Yuan; Chun-Nan OuYang; David M Ojcius; Chih-Ching Wu; Yu-Sun Chang
Journal:  Mol Cell Proteomics       Date:  2019-11-13       Impact factor: 5.911

3.  LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis.

Authors:  Qiaosu Wang; Wenjing Zhang; Shaojuan Hao
Journal:  Cell Cycle       Date:  2017-03-30       Impact factor: 4.534

4.  MicroRNA-663b promotes cell proliferation and epithelial mesenchymal transition by directly targeting SMAD7 in nasopharyngeal carcinoma.

Authors:  Meirong Wang; Min Jia; Kun Yuan
Journal:  Exp Ther Med       Date:  2018-08-07       Impact factor: 2.447

5.  Salinomycin may inhibit the cancer stem-like populations with increased chemoradioresistance that nasopharyngeal cancer tumorspheres contain.

Authors:  Gong Zhang; Shuping Zhang; Jinjin Ren; Chunxiao Yao; Zhongren Zhao; Xiurong Qi; Xiaofeng Zhang; Shuye Wang; Lei Li
Journal:  Oncol Lett       Date:  2018-06-07       Impact factor: 2.967

6.  Radiation-resistant cancer stem-like cell properties are regulated by PTEN through the activity of nuclear β-catenin in nasopharyngeal carcinoma.

Authors:  Gong Zhang; Wenjun Wang; Chunxiao Yao; Shuping Zhang; Lili Liang; Muyuan Han; Jinjin Ren; Xiurong Qi; Xiaofeng Zhang; Shuye Wang; Lei Li
Journal:  Oncotarget       Date:  2017-08-18

7.  miR-663b promotes tumor cell proliferation, migration and invasion in nasopharyngeal carcinoma through targeting TUSC2.

Authors:  Shaoqiang Liang; Ning Zhang; Yanming Deng; Lusi Chen; Yang Zhang; Zhenhe Zheng; Weijun Luo; Zhiqian Lv; Shaoen Li; Tao Xu
Journal:  Exp Ther Med       Date:  2017-06-14       Impact factor: 2.447

8.  Curcumin exerts its antitumor activity through regulation of miR-7/Skp2/p21 in nasopharyngeal carcinoma cells.

Authors:  Shaoyan Feng; Yu Wang; Rongkai Zhang; Guangwei Yang; Zibin Liang; Zhiwei Wang; Gehua Zhang
Journal:  Onco Targets Ther       Date:  2017-05-02       Impact factor: 4.147

9.  Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in nasopharyngeal carcinoma patients with cervical nodal necrosis.

Authors:  Mei Lan; Chunyan Chen; Ying Huang; Li Tian; Zhijun Duan; Fei Han; Junfang Liao; Meiling Deng; Terence T Sio; Anussara Prayongrat; Lie Zheng; Shaoxiong Wu; Taixiang Lu
Journal:  Sci Rep       Date:  2017-02-17       Impact factor: 4.379

10.  Increased Serum Level of MicroRNA-663 Is Correlated with Poor Prognosis of Patients with Nasopharyngeal Carcinoma.

Authors:  Shaoqiang Liang; Ning Zhang; Yanming Deng; Lusi Chen; Yang Zhang; Zhenhe Zheng; Weijun Luo; Zhiqian Lv; Shaoen Li; Tao Xun
Journal:  Dis Markers       Date:  2016-09-07       Impact factor: 3.434
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