Xiao Yang1, Guizhi Sun2, Jinxue Wei1,3, Bin Huang1, Liansheng Zhao1,3, Yingcheng Wang1,3, Bo Zhou4, Li Tao1,3, Xiaohong Ma5,6. 1. Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China. 2. Department of Psychiatry, Binzhou Medical University Hospital, Binzhou, China. 3. National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. 4. Center of Psychosomatic Medicine, Sichuan Provincial People's Hospital, Chengdu, China. 5. Psychiatric Laboratory and Department of Psychiatry, West China Hospital, Sichuan University, Chengdu, China. maxiaohong@scu.edu.cn. 6. National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. maxiaohong@scu.edu.cn.
Abstract
OBJECTIVE: The aim of this study was to compare hair thyroid hormone (TH) levels among first-episode patients with major depressive disorder (F-MDD), recurrent patients with major depressive disorder (R-MDD) and healthy controls (HC). METHODS: The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate the clinical symptoms of patients. Electrochemiluminescence immunoassay was used to measure the hair TH levels. We compared the differences in hair TH levels among F-MDD patients, R-MDD patients, and HC. RESULTS: Before the disease episode, hair T3 levels differed significantly between F-MDD patients and HC. In the disease episode, hair T3 levels differed significantly between F-MDD or R-MDD patients and HC; and hair T4 levels differed significantly between R-MDD patients and HC. Hair T3 levels significantly negative correlated with HAMD scores in F-MDD patients. CONCLUSIONS: Our findings suggested that disease duration of recurring episodes of depression may influence hair TH levels.
OBJECTIVE: The aim of this study was to compare hair thyroid hormone (TH) levels among first-episode patients with major depressive disorder (F-MDD), recurrent patients with major depressive disorder (R-MDD) and healthy controls (HC). METHODS: The Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to evaluate the clinical symptoms of patients. Electrochemiluminescence immunoassay was used to measure the hair TH levels. We compared the differences in hair TH levels among F-MDDpatients, R-MDDpatients, and HC. RESULTS: Before the disease episode, hair T3 levels differed significantly between F-MDDpatients and HC. In the disease episode, hair T3 levels differed significantly between F-MDD or R-MDDpatients and HC; and hair T4 levels differed significantly between R-MDDpatients and HC. Hair T3 levels significantly negative correlated with HAMD scores in F-MDDpatients. CONCLUSIONS: Our findings suggested that disease duration of recurring episodes of depression may influence hair TH levels.