Mehmet Faruk Çatma1, Hakan Şeşen2, Aytekin Aydın1, Serhan Ünlü1, İsmail Demirkale2, Murat Altay2. 1. Departments of Orthopaedics and Traumatology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey. 2. Departments of Orthopaedics and Traumatology, Ankara Keçiören Education and Research Hospital, Ankara, Turkey.
Abstract
PURPOSE: We hypothesized that RIP accelerates fracture healing. METHODS: Rats (n = 48) were used for the technique of ischemic preconditioning involved applying 35 min of intermittent pneumatic tourniquet for 7 cycles of 5 min each to the fractured hind limb. RESULTS: We observed greater callus maturity in RIP group at first week after fracture when compared to controls (p < 0,0001). The serum MDA levels demonstrated statistically lower values at the RIP group at the first week after fracture; however, there were not significant differences at 3rd and 5th weeks (p = 0.0001, p = 0.725, p = 0.271, respectively). CONCLUSIONS: Greater callus maturity was obtained in RIP group.
PURPOSE: We hypothesized that RIP accelerates fracture healing. METHODS:Rats (n = 48) were used for the technique of ischemic preconditioning involved applying 35 min of intermittent pneumatic tourniquet for 7 cycles of 5 min each to the fractured hind limb. RESULTS: We observed greater callus maturity in RIP group at first week after fracture when compared to controls (p < 0,0001). The serum MDA levels demonstrated statistically lower values at the RIP group at the first week after fracture; however, there were not significant differences at 3rd and 5th weeks (p = 0.0001, p = 0.725, p = 0.271, respectively). CONCLUSIONS: Greater callus maturity was obtained in RIP group.
Authors: Muhammad U Jawad; Kate E Fritton; Ting Ma; Pei-Gen Ren; Stuart B Goodman; Hua Z Ke; Philip Babij; Mark C Genovese Journal: J Orthop Res Date: 2012-08-08 Impact factor: 3.494