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Literature DB >> 26565989

Functional and structural characterization of a heparanase.

Lisa Bohlmann¹, Gregory D Tredwell¹, Xing Yu¹, Chih-Wei Chang¹, Thomas Haselhorst¹, Moritz Winger¹, Jeffrey C Dyason¹, Robin J Thomson¹, Joe Tiralongo¹, Ifor R Beacham¹, Helen Blanchard¹, Mark von Itzstein¹.

Abstract

We report the structural and functional characterization of a novel heparanase (BpHep) from the invasive pathogenic bacterium Burkholderia pseudomallei (Bp), showing ∼24% sequence identity with human heparanase (hHep). Site-directed mutagenesis studies confirmed the active site resi-dues essential for activity, and we found that BpHep has specificity for heparan sulfate. Finally, we describe the first heparanase X-ray crystal structure, which provides new insight into both substrate recognition and inhibitor design.

Entities: Chemical Gene Species

Mesh：

Substances：
heparanase
Glucuronidase

Year: 2015 PMID： 26565989 DOI： 10.1038/nchembio.1956

Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040

33 in total

1. SFCHECK: a unified set of procedures for evaluating the quality of macromolecular structure-factor data and their agreement with the atomic model.

Authors: A A Vaguine; J Richelle; S J Wodak
Journal: Acta Crystallogr D Biol Crystallogr Date: 1999-01-01

Review 2. Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.

Authors: Neta Ilan; Michael Elkin; Israel Vlodavsky
Journal: Int J Biochem Cell Biol Date: 2006-07-06 Impact factor: 5.085

3. Synthesis of simple heparanase substrates.

Authors: Andrew G Pearson; Milton J Kiefel; Vito Ferro; Mark von Itzstein
Journal: Org Biomol Chem Date: 2011-04-20 Impact factor: 3.876

4. Molecular model of human heparanase with proposed binding mode of a heparan sulfate oligosaccharide and catalytic amino acids.

Authors: Nicolas Sapay; Eric Cabannes; Maurice Petitou; Anne Imberty
Journal: Biopolymers Date: 2011-07-21 Impact factor: 2.505

5. iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM.

Authors: T Geoff G Battye; Luke Kontogiannis; Owen Johnson; Harold R Powell; Andrew G W Leslie
Journal: Acta Crystallogr D Biol Crystallogr Date: 2011-03-18

6. Processing of macromolecular heparin by heparanase.

Authors: Feng Gong; Per Jemth; Martha L Escobar Galvis; Israel Vlodavsky; Alan Horner; Ulf Lindahl; Jin-ping Li
Journal: J Biol Chem Date: 2003-07-01 Impact factor: 5.157

7. High-throughput methods for measuring heparanase activity and screening potential antimetastatic and anti-inflammatory agents.

Authors: Kuo-Sen Huang; Janna Holmgren; Linda Reik; Debra Lucas-McGady; John Roberts; Chao-Min Liu; Wayne Levin
Journal: Anal Biochem Date: 2004-10-15 Impact factor: 3.365

Review 8. Scaling and assessment of data quality.

Authors: Philip Evans
Journal: Acta Crystallogr D Biol Crystallogr Date: 2005-12-14

9. Synthesis of a pseudo-disaccharide library and its application to the characterisation of the heparanase catalytic site.

Authors: Victoria Vinader; Mohamed H Haji-Abdullahi; L H Patterson; Kamyar Afarinkia
Journal: PLoS One Date: 2013-11-18 Impact factor: 3.240

10. Phaser crystallographic software.

Authors: Airlie J McCoy; Ralf W Grosse-Kunstleve; Paul D Adams; Martyn D Winn; Laurent C Storoni; Randy J Read
Journal: J Appl Crystallogr Date: 2007-07-13 Impact factor: 3.304

13 in total

1. Specificity and action pattern of heparanase Bp, a β-glucuronidase from Burkholderia pseudomallei.

Authors: Yanlei Yu; Asher Williams; Xing Zhang; Li Fu; Ke Xia; Yongmei Xu; Fuming Zhang; Jian Liu; Mattheos Koffas; Robert J Linhardt
Journal: Glycobiology Date: 2019-07-19 Impact factor: 4.313

Review 2. Advances in the preparation and synthesis of heparin and related products.

Authors: Sultan N Baytas; Robert J Linhardt
Journal: Drug Discov Today Date: 2020-09-16 Impact factor: 7.851

3. Activity-based probes for functional interrogation of retaining β-glucuronidases.

Authors: Liang Wu; Jianbing Jiang; Yi Jin; Wouter W Kallemeijn; Chi-Lin Kuo; Marta Artola; Wei Dai; Cas van Elk; Marco van Eijk; Gijsbert A van der Marel; Jeroen D C Codée; Bogdan I Florea; Johannes M F G Aerts; Herman S Overkleeft; Gideon J Davies
Journal: Nat Chem Biol Date: 2017-06-05 Impact factor: 15.040

Review 4. Mass Spectrometry-Based Techniques to Elucidate the Sugar Code.

Authors: Márkó Grabarics; Maike Lettow; Carla Kirschbaum; Kim Greis; Christian Manz; Kevin Pagel
Journal: Chem Rev Date: 2021-09-07 Impact factor: 72.087

Review 5. Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.

Authors: Israel Vlodavsky; Miriam Gross-Cohen; Marina Weissmann; Neta Ilan; Ralph D Sanderson
Journal: Trends Biochem Sci Date: 2017-11-20 Impact factor: 13.807

6. On the Biology of Werner's Complex.

Authors: Raphael E F de Paiva; Erica J Peterson; Jaroslav Malina; Mary Zoepfl; J David Hampton; Wyatt E Johnson; Angelica Graminha; Amine Ourahmane; Michael A McVoy; Viktor Brabec; Susan J Berners-Price; Nicholas P Farrell
Journal: Angew Chem Int Ed Engl Date: 2021-06-27 Impact factor: 16.823