Literature DB >> 26565561

The value of routine pharmacogenomic screening-Are we there yet? A perspective on the costs and benefits of routine screening-shouldn't everyone have this done?

D L Veenstra1.   

Abstract

Although there are several examples in which pharmacogenomic testing seems to provide clinical and economic value, use of pharmacogenomics as a tool to improve drug therapy through routine screening of unselected patients is currently tentative. An informal evaluation of the clinical benefits and economic costs of pharmacogenomic screening suggests that improving the evidence base, addressing uncertainty, and facilitating implementation can lead to practical and cost-effective pharmacogenomic screening programs.
© 2015 ASCPT.

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Year:  2015        PMID: 26565561      PMCID: PMC5341789          DOI: 10.1002/cpt.299

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  10 in total

1.  Aggregate cost of mammography screening in the United States: comparison of current practice and advocated guidelines.

Authors:  Cristina O'Donoghue; Martin Eklund; Elissa M Ozanne; Laura J Esserman
Journal:  Ann Intern Med       Date:  2014-02-04       Impact factor: 25.391

2.  A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testing.

Authors:  Lisa M Meckley; James M Gudgeon; Jeffrey L Anderson; Marc S Williams; David L Veenstra
Journal:  Pharmacoeconomics       Date:  2010       Impact factor: 4.981

3.  Effects of a HLA-B*15:02 screening policy on antiepileptic drug use and severe skin reactions.

Authors:  Zhibin Chen; Danny Liew; Patrick Kwan
Journal:  Neurology       Date:  2014-10-29       Impact factor: 9.910

4.  The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.

Authors:  Bruce R Schackman; Callie A Scott; Rochelle P Walensky; Elena Losina; Kenneth A Freedberg; Paul E Sax
Journal:  AIDS       Date:  2008-10-01       Impact factor: 4.177

5.  Economic evaluation of HLA-B*15:02 screening for carbamazepine-induced severe adverse drug reactions in Thailand.

Authors:  Waranya Rattanavipapong; Tanunya Koopitakkajorn; Naiyana Praditsitthikorn; Surakameth Mahasirimongkol; Yot Teerawattananon
Journal:  Epilepsia       Date:  2013-07-29       Impact factor: 5.864

6.  Cost-effectiveness of HLA-B*1502 genotyping in adult patients with newly diagnosed epilepsy in Singapore.

Authors:  Di Dong; Cynthia Sung; Eric Andrew Finkelstein
Journal:  Neurology       Date:  2012-09-05       Impact factor: 9.910

7.  A risk-benefit assessment of prasugrel, clopidogrel, and genotype-guided therapy in patients undergoing percutaneous coronary intervention.

Authors:  G F Guzauskas; D A Hughes; S M Bradley; D L Veenstra
Journal:  Clin Pharmacol Ther       Date:  2012-03-28       Impact factor: 6.875

8.  Clinically actionable genotypes among 10,000 patients with preemptive pharmacogenomic testing.

Authors:  S L Van Driest; Y Shi; E A Bowton; J S Schildcrout; J F Peterson; J Pulley; J C Denny; D M Roden
Journal:  Clin Pharmacol Ther       Date:  2013-11-19       Impact factor: 6.875

9.  Cost-effectiveness of pharmacogenetics-guided warfarin therapy vs. alternative anticoagulation in atrial fibrillation.

Authors:  J Pink; M Pirmohamed; S Lane; D A Hughes
Journal:  Clin Pharmacol Ther       Date:  2013-09-23       Impact factor: 6.875

10.  The cost-effectiveness of returning incidental findings from next-generation genomic sequencing.

Authors:  Caroline S Bennette; Carlos J Gallego; Wylie Burke; Gail P Jarvik; David L Veenstra
Journal:  Genet Med       Date:  2014-11-13       Impact factor: 8.822

  10 in total
  2 in total

Review 1.  Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward.

Authors:  Kelly E Caudle; Nicholas J Keeling; Teri E Klein; Michelle Whirl-Carrillo; Victoria M Pratt; James M Hoffman
Journal:  Pharmacogenomics       Date:  2018-06-19       Impact factor: 2.533

Review 2.  HLAs: Key regulators of T-cell-mediated drug hypersensitivity.

Authors:  A J Redwood; R K Pavlos; K D White; E J Phillips
Journal:  HLA       Date:  2018-01       Impact factor: 4.513

  2 in total

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