| Literature DB >> 26565429 |
Monica Sager1,2, Nai Chien Yeat2,3, Stefan Pajaro-Van der Stadt1,2, Charlotte Lin2,3, Qiuyin Ren2,4, Jimmy Lin2.
Abstract
Transcriptomic technologies are evolving to diagnose cancer earlier and more accurately to provide greater predictive and prognostic utility to oncologists and patients. Digital techniques such as RNA sequencing are replacing still-imaging techniques to provide more detailed analysis of the transcriptome and aberrant expression that causes oncogenesis, while companion diagnostics are developing to determine the likely effectiveness of targeted treatments. This article examines recent advancements in molecular profiling research and technology as applied to cancer diagnosis, clinical applications and predictions for the future of personalized medicine in oncology.Entities:
Keywords: RNA sequencing; Transcriptomics; cancer; companion diagnostics; microarray; molecular diagnostics; personalized medicine; quantitative reverse transcription PCR (RT-qPCR); serial analysis of gene expression (SAGE)
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Year: 2015 PMID： 26565429 DOI： 10.1586/14737159.2015.1105133
Source DB: PubMed Journal: Expert Rev Mol Diagn ISSN： 1473-7159 Impact factor: 5.225