Literature DB >> 26564116

Metastatic choriocarcinoma induced separate simultaneous intracerebral haemorrhages: a very rare occurrence and its novel association with Klinefelter syndrome.

Maximilian Olavi Joret1, Robert M Starke2, John Scotter3, Peter Heppner3.   

Abstract

Non-traumatic separate simultaneous intracerebral haemorrhages (SSIHs) are rare. Relevant aetiologies are diverse and their diagnosis challenging. We report a unique case of SSIH in an 18-year-old male with a background of previously undiagnosed testicular choriocarcinoma and Klinefelter syndrome. The patient was admitted to Auckland City Hospital with headaches, drowsiness and vomiting. A CT scan revealed SSIH in a background of tumorous lesions. His β human chorionic gonadotropin titre was elevated at 355 000 IU/L. The SSIH and the associated tumorous lesions were acutely surgically resected and the patient started on bleomycin, etoposide and cisplatin combination chemotherapy with excellent results. In this article, we underline choriocarcinoma as a rare aetiology of SSIH and present an example of the clinical presentation, investigation and management of this very rare pathological entity. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID: 26564116      PMCID: PMC4654026          DOI: 10.1136/bcr-2015-212777

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  13 in total

1.  Metastatic choriocarcinoma presenting as multiple intracerebral haemorrhages: the role of imaging in the elucidation of the pathology.

Authors:  D Kidd; G T Plant; F Scaravilli; A C McCartney; M Stanford; E M Graham
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-12       Impact factor: 10.154

2.  Remote cerebral and cerebellar hemorrhage after massive cerebrospinal fluid leakage.

Authors:  Sung-Hye You; Kyu Ri Son; Nam Joon Lee; Jung-Keun Suh
Journal:  J Korean Neurosurg Soc       Date:  2012-04-30

3.  Multiple intracerebral hematomas without tumor: report of an unusual case.

Authors:  H Tachibana; T Mine; T Sasaki; M Nara; K Ono
Journal:  Keio J Med       Date:  1978-04

4.  Multiple simultaneous intracerebral hemorrhages: clinical features and outcome.

Authors:  J Mauriño; G Saposnik; S Lepera; R C Rey; R E Sica
Journal:  Arch Neurol       Date:  2001-04

5.  Advanced testicular cancer associated with life-threatening tumour lysis syndrome and choriocarcinoma syndrome.

Authors:  Kohei Kobatake; Masao Kato; Koji Mita
Journal:  Can Urol Assoc J       Date:  2015 Jan-Feb       Impact factor: 1.862

6.  Disseminated cerebral hemorrhages as unusual manifestation of toxoplasmic encephalitis in AIDS.

Authors:  P Berlit; O Popescu; Y Weng; R Malessa
Journal:  J Neurol Sci       Date:  1996-11       Impact factor: 3.181

7.  Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome.

Authors:  G G Bebb; F W Grannis; I B Paz; M L Slovak; R Chilcote
Journal:  Ann Thorac Surg       Date:  1998-08       Impact factor: 4.330

8.  Multiple cavernomas of brain presenting with simultaneous hemorrhage in two lesions: a case report.

Authors:  Amitabha Chanda; Anil Nanda
Journal:  Surg Neurol       Date:  2002-05

9.  Mixed testicular germ cell tumor presenting as metastatic pure choriocarcinoma involving multiple lung metastases that was effectively treated with high-dose chemotherapy.

Authors:  Sang-Cheol Lee; Kyoung Ha Kim; Sung Han Kim; Nam Su Lee; Hee Sook Park; Jong-Ho Won
Journal:  Cancer Res Treat       Date:  2009-12-31       Impact factor: 4.679

10.  Intracranial hemorrhage caused by metastatic tumors.

Authors:  T I Mandybur
Journal:  Neurology       Date:  1977-07       Impact factor: 9.910

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