| Literature DB >> 26563651 |
M Margaret Harris1, Zachary Coon, Najah Alqaeisoom, Brian Swords, Justin M Holub.
Abstract
BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.Entities:
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Year: 2016 PMID： 26563651 DOI： 10.1039/c5ob02080h
Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876