Sunil Kumar1, Raymond Lau2, Christopher Hall1, Thomas Palaia1, Collin E Brathwaite3, Louis Ragolia4. 1. Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA. 2. Department of Surgery, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Endocrinology, Winthrop University Hospital, Mineola, NY 11501, USA. 3. Department of Surgery, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. 4. Department of Biomedical Research, Winthrop University Hospital, Mineola, NY 11501, USA; Department of Medicine, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA. Electronic address: LRagolia@Winthrop.org.
Abstract
BACKGROUND: Roux-en-Y gastric bypass (RYGB) may improve cardiometabolic risk through alteration of bile acids and L-PGDS levels. OBJECTIVE: The objective of this study was to investigate the effect of RYGB on aortic wall thickness, in relation to bile acid and L-PGDS metabolism. METHODS: Zucker diabetic fatty (ZDF) rats were divided into two groups, ad lib (n = 4), and RYGB (n = 6). Bile acid and L-PGDS were measured presurgery and fourteen weeks post-surgery. RESULTS: Elevation of bile acid levels following RYGB in Zucker Diabetic Fatty (ZDF) rodents was observed, as compared to ad lib. RYGB in ZDF rodents led to a significantly decreased aortic wall thickness (25%) as compared to ad lib control. Although bile acid metabolism is implicated in these alterations, other mediators are likely involved. Our laboratory has demonstrated lipocalin prostaglandin D2 synthase (L-PGDS) is a kno n cardiometabolic modulator that also functions as a bile acid binding protein. Therefore, L-PGDS levels were measured and a significant elevation was observed with RYGB compared to ad lib control. CONCLUSION: Based on these findings, RYGB showed beneficial effect on aortic wall thickness, possibly through bile acids and L-PGDS elevation in a severely obese and diabetic rodent model.
BACKGROUND: Roux-en-Y gastric bypass (RYGB) may improve cardiometabolic risk through alteration of bile acids and L-PGDS levels. OBJECTIVE: The objective of this study was to investigate the effect of RYGB on aortic wall thickness, in relation to bile acid and L-PGDS metabolism. METHODS: Zucker diabetic fatty (ZDF) rats were divided into two groups, ad lib (n = 4), and RYGB (n = 6). Bile acid and L-PGDS were measured presurgery and fourteen weeks post-surgery. RESULTS: Elevation of bile acid levels following RYGB in Zucker Diabetic Fatty (ZDF) rodents was observed, as compared to ad lib. RYGB in ZDF rodents led to a significantly decreased aortic wall thickness (25%) as compared to ad lib control. Although bile acid metabolism is implicated in these alterations, other mediators are likely involved. Our laboratory has demonstrated lipocalin prostaglandin D2 synthase (L-PGDS) is a kno n cardiometabolic modulator that also functions as a bile acid binding protein. Therefore, L-PGDS levels were measured and a significant elevation was observed with RYGB compared to ad lib control. CONCLUSION: Based on these findings, RYGB showed beneficial effect on aortic wall thickness, possibly through bile acids and L-PGDS elevation in a severely obese and diabetic rodent model.
Authors: Sunil Kumar; Raymond Lau; Thomas Palaia; Christopher Hall; Jenny Lee; Keneth Hall; Collin E Brathwaite; Louis Ragolia Journal: Ann Med Surg (Lond) Date: 2016-11-17