Literature DB >> 26563160

Recurrent Respiratory Infections Revealing CD8α Deficiency.

Erwan Dumontet1,2, Jennifer Osman1, Nathalie Guillemont-Lambert3, Guilhem Cros4,5, Despina Moshous4,5,6, Capucine Picard7,8,9,10,11,12.   

Abstract

CD8A encodes the CD8α chain of the dimeric CD8 protein, a critical coreceptor of cytotoxic T cells. We report here the comprehensive immunological evaluation of a child with a CD8A missense mutation, providing evidence that CD8 deficiency increases susceptibility to recurrent respiratory infections without interfering with the TCR-mediated proliferation of T cells. These observations expand the known phenotypes associated with CD8 deficiency.

Entities:  

Keywords:  CD8; CD8A; CID combined immune deficiency; TCR signaling; immunophenotyping

Mesh：

Substances：

Year:  2015        PMID： 26563160     DOI： 10.1007/s10875-015-0213-x

Source DB:  PubMed          Journal:  J Clin Immunol        ISSN： 0271-9142            Impact factor:   8.317


  12 in total

1.  Predicting deleterious amino acid substitutions.

Authors:  P C Ng; S Henikoff
Journal:  Genome Res       Date:  2001-05       Impact factor: 9.043

Review 2.  Molecular coordination of alphabeta T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands.

Authors:  George F Gao; Zihe Rao; John I Bell
Journal:  Trends Immunol       Date:  2002-08       Impact factor: 16.687

3.  SIFT: Predicting amino acid changes that affect protein function.

Authors:  Pauline C Ng; Steven Henikoff
Journal:  Nucleic Acids Res       Date:  2003-07-01       Impact factor: 16.971

Review 4.  CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

Authors:  R Zamoyska
Journal:  Curr Opin Immunol       Date:  1998-02       Impact factor: 7.486

5.  Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8).

Authors:  K Nakayama; S Tokito; K Okumura; H Nakauchi
Journal:  Immunogenetics       Date:  1989       Impact factor: 2.846

Review 6.  Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells.

Authors:  R Tarazona; O DelaRosa; C Alonso; B Ostos; J Espejo; J Peña; R Solana
Journal:  Mech Ageing Dev       Date:  2000-12-20       Impact factor: 5.432

7.  Four functionally distinct populations of human effector-memory CD8+ T lymphocytes.

Authors:  Pedro Romero; Alfred Zippelius; Isabel Kurth; Mikaël J Pittet; Cédric Touvrey; Emanuela M Iancu; Patricia Corthesy; Estelle Devevre; Daniel E Speiser; Nathalie Rufer
Journal:  J Immunol       Date:  2007-04-01       Impact factor: 5.422

8.  A method and server for predicting damaging missense mutations.

Authors:  Ivan A Adzhubei; Steffen Schmidt; Leonid Peshkin; Vasily E Ramensky; Anna Gerasimova; Peer Bork; Alexey S Kondrashov; Shamil R Sunyaev
Journal:  Nat Methods       Date:  2010-04       Impact factor: 28.547

9.  Gly111Ser mutation in CD8A gene causing CD8 immunodeficiency is found in Spanish Gypsies.

Authors:  Esther Mancebo; Miguel A Moreno-Pelayo; Angeles Mencía; Oscar de la Calle-Martín; Luis M Allende; Padma Sivadorai; Luba Kalaydjieva; Jaume Bertranpetit; Eliecer Coto; Sara Calleja-Antolín; Jesus Ruiz-Contreras; Estela Paz-Artal
Journal:  Mol Immunol       Date:  2007-07-20       Impact factor: 4.407

10.  Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people.

Authors:  Sven Koch; Anis Larbi; Evelyna Derhovanessian; Dennis Ozcelik; Elissaveta Naumova; Graham Pawelec
Journal:  Immun Ageing       Date:  2008-07-25       Impact factor: 6.400
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  2 in total

1.  Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells.

Authors:  Matthew B Dong; Guangchuan Wang; Ryan D Chow; Lupeng Ye; Lvyun Zhu; Xiaoyun Dai; Jonathan J Park; Hyunu R Kim; Youssef Errami; Christopher D Guzman; Xiaoyu Zhou; Krista Y Chen; Paul A Renauer; Yaying Du; Johanna Shen; Stanley Z Lam; Jingjia J Zhou; Donald R Lannin; Roy S Herbst; Sidi Chen
Journal:  Cell       Date:  2019-08-22       Impact factor: 41.582

2.  Identification of key miRNA‑mRNA pairs in septic mice by bioinformatics analysis.

Authors:  Jianxin Chen; Min Lin; Sen Zhang
Journal:  Mol Med Rep       Date:  2019-08-20       Impact factor: 2.952
  2 in total

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