| Literature DB >> 26561523 |
Paul S de Vries1, Daniel I Chasman2, Maria Sabater-Lleal3, Ming-Huei Chen4, Jennifer E Huffman5, Maristella Steri6, Weihong Tang7, Alexander Teumer8, Riccardo E Marioni9, Vera Grossmann10, Jouke J Hottenga11, Stella Trompet12, Martina Müller-Nurasyid13, Jing Hua Zhao14, Jennifer A Brody15, Marcus E Kleber16, Xiuqing Guo17, Jie Jin Wang18, Paul L Auer19, John R Attia20, Lisa R Yanek21, Tarunveer S Ahluwalia22, Jari Lahti23, Cristina Venturini24, Toshiko Tanaka25, Lawrence F Bielak26, Peter K Joshi27, Ares Rocanin-Arjo28, Ivana Kolcic29, Pau Navarro30, Lynda M Rose31, Christopher Oldmeadow20, Helene Riess32, Johanna Mazur33, Saonli Basu34, Anuj Goel35, Qiong Yang36, Mohsen Ghanbari37, Gonneke Willemsen11, Ann Rumley38, Edoardo Fiorillo6, Anton J M de Craen39, Anne Grotevendt40, Robert Scott14, Kent D Taylor41, Graciela E Delgado16, Jie Yao41, Annette Kifley18, Charles Kooperberg42, Rehan Qayyum21, Lorna M Lopez43, Tina L Berentzen44, Katri Räikkönen45, Massimo Mangino46, Stefania Bandinelli47, Patricia A Peyser26, Sarah Wild48, David-Alexandre Trégouët28, Alan F Wright30, Jonathan Marten30, Tatijana Zemunik49, Alanna C Morrison50, Bengt Sennblad51, Geoffrey Tofler52, Moniek P M de Maat53, Eco J C de Geus54, Gordon D Lowe38, Magdalena Zoledziewska6, Naveed Sattar55, Harald Binder33, Uwe Völker56, Melanie Waldenberger57, Kay-Tee Khaw58, Barbara Mcknight59, Jie Huang60, Nancy S Jenny61, Elizabeth G Holliday62, Lihong Qi63, Mark G Mcevoy64, Diane M Becker21, John M Starr65, Antti-Pekka Sarin66, Pirro G Hysi46, Dena G Hernandez67, Min A Jhun26, Harry Campbell68, Anders Hamsten3, Fernando Rivadeneira69, Wendy L Mcardle70, P Eline Slagboom71, Tanja Zeller72, Wolfgang Koenig73, Bruce M Psaty74, Talin Haritunians75, Jingmin Liu42, Aarno Palotie76, André G Uitterlinden69, David J Stott77, Albert Hofman1, Oscar H Franco1, Ozren Polasek78, Igor Rudan68, Pierre-Emmanuel Morange79, James F Wilson80, Sharon L R Kardia26, Luigi Ferrucci25, Tim D Spector46, Johan G Eriksson81, Torben Hansen82, Ian J Deary83, Lewis C Becker21, Rodney J Scott84, Paul Mitchell18, Winfried März85, Nick J Wareham14, Annette Peters86, Andreas Greinacher87, Philipp S Wild88, J Wouter Jukema89, Dorret I Boomsma11, Caroline Hayward30, Francesco Cucca6, Russell Tracy90, Hugh Watkins35, Alex P Reiner91, Aaron R Folsom7, Paul M Ridker2, Christopher J O'Donnell92, Nicholas L Smith93, David P Strachan94, Abbas Dehghan95.
Abstract
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.Entities:
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Year: 2015 PMID： 26561523 PMCID： PMC4715256 DOI： 10.1093/hmg/ddv454
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150