Erin Wachter1, Diego Moyá1, Sean Parkin1, Edith C Glazer2. 1. Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506 (USA). 2. Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, KY 40506 (USA). ec.glazer@uky.edu.
Abstract
Recognition and regulation of G-quadruplex nucleic acid structures is an important goal for the development of chemical tools and medicinal agents. The addition of a bromo-substituent to the dipyridylphenazine (dppz) ligands in the photophysical "light switch", [Ru(bpy)2 dppz](2+) , and the photochemical "light switch", [Ru(bpy)2 dmdppz](2+) , creates compounds with increased selectivity for an intermolecular parallel G-quadruplex and the mixed-hybrid G-quadruplex, respectively. When [Ru(bpy)2 dppz-Br](2+) and [Ru(bpy)2 dmdppz-Br](2+) are incubated with the G-quadruplexes, they have a stabilizing effect on the DNA structures. Activation of [Ru(bpy)2 dmdppz-Br](2+) with light results in covalent adduct formation with the DNA. These complexes demonstrate that subtle chemical modifications of Ru(II) complexes can alter G-quadruplex selectivity, and could be useful for the rational design of in vivo G-quadruplex probes.
Recognition and regulation of G-quadn class="Chemical">ruplex nucleic acid structures is an important goal for the development of chemical tools and medicinal agents. The addition of a bromo-substituent to the dipyridylphenazine (dppz) ligands in the photophysical "light switch", [Ru(bpy)2 dppz](2+) , and the photochemical "light switch", [Ru(bpy)2 dmdppz](2+) , creates compounds with increased selectivity for an intermolecular parallel G-quadruplex and the mixed-hybrid G-quadruplex, respectively. When [Ru(bpy)2 dppz-Br](2+) and [Ru(bpy)2 dmdppz-Br](2+) are incubated with the G-quadruplexes, they have a stabilizing effect on the DNA structures. Activation of [Ru(bpy)2 dmdppz-Br](2+) with light results in covalent adduct formation with the DNA. These complexes demonstrate that subtle chemical modifications of Ru(II)complexes can alter G-quadruplex selectivity, and could be useful for the rational design of in vivo G-quadruplex probes.
Authors: Chad M Shade; Robert D Kennedy; Jessica L Rouge; Mari S Rosen; Mary X Wang; Soyoung E Seo; Daniel J Clingerman; Chad A Mirkin Journal: Chemistry Date: 2015-06-26 Impact factor: 5.236
Authors: Anna J McConnell; Mi Hee Lim; Eric D Olmon; Hang Song; Elizabeth E Dervan; Jacqueline K Barton Journal: Inorg Chem Date: 2012-10-31 Impact factor: 5.165
Authors: Michael P O'Hagan; Susanta Haldar; Marta Duchi; Thomas A A Oliver; Adrian J Mulholland; Juan C Morales; M Carmen Galan Journal: Angew Chem Int Ed Engl Date: 2019-02-20 Impact factor: 15.336
Authors: Luke K McKenzie; Marie Flamme; Patrick S Felder; Johannes Karges; Frederic Bonhomme; Albert Gandioso; Christian Malosse; Gilles Gasser; Marcel Hollenstein Journal: RSC Chem Biol Date: 2021-11-02
Authors: Fergus E Poynton; James P Hall; Páraic M Keane; Christine Schwarz; Igor V Sazanovich; Michael Towrie; Thorfinnur Gunnlaugsson; Christine J Cardin; David J Cardin; Susan J Quinn; Conor Long; John M Kelly Journal: Chem Sci Date: 2016-01-27 Impact factor: 9.825